Bis-aromatic Amide Sweeteners Receptor Binding
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Solution Overview
Problem
There is a need for new and improved flavoring agents and sweeteners that can induce sweetness at extremely low concentrations and enhance the sweetness of existing natural or artificial sweeteners, particularly to address the growing issues of weight gain and associated diseases like diabetes.
Innovation Solution
Development of bis-aromatic amide compounds that bind to T1R2/T1R3 sweet receptors at low concentrations, acting as high-intensity sweeteners or sweet flavor enhancers when combined with other sweeteners, thereby reducing the required amounts of caloric sweeteners in food and beverage compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If high-intensity sweeteners are used to reduce caloric sweetener amounts, then sweetness perception is improved at low concentrations, but the complexity of flavor formulation increases
Solution Approach 1:
The patent applies parameter changes by systematically varying molecular structures of amide compounds (changing chemical parameters) to achieve optimal sweetness intensity and receptor binding affinity. This allows formulation of high-intensity sweeteners that deliver potent sweetness at extremely low concentrations while maintaining manageable formulation complexity through structure-activity relationship optimization
Solution Approach 2:
The patent employs composite materials by combining bis-aromatic amide compounds with existing sweeteners or flavor compounds to create synergistic formulations. These composite flavor compositions leverage the high sweetness intensity of the amide compounds while incorporating complementary compounds to achieve balanced flavor profiles, thereby managing overall formulation complexity
2Quantity of substance
If new high-intensity sweeteners are discovered, then sweetness induction at low concentrations is improved, but the time and resources required for discovery and development increase
Solution Approach 1:
The patent applies preliminary action by conducting extensive in silico modeling and in vitro screening of amide compound derivatives before proceeding to in vivo testing and commercial development. This preliminary characterization of structure-activity relationships and receptor binding properties of various amide structures accelerates the discovery process by identifying promising candidates early, reducing overall development time and resource investment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These bis-aromatic amide compounds effectively activate sweet receptors at micromolar concentrations, allowing for the formulation of comestible compositions with lower levels of traditional sweeteners, providing a high-intensity sweet taste while addressing health concerns related to sugar consumption.
Implementation Method 1
bis-aromatic amide compounds that bind to T1R2/T1R3 sweet receptors at low concentrations
Data Source
AI summary
The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.