Bisamide Insecticide Composition for Resistance-Prone Pest Control
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Solution Overview
Problem
Existing insecticides face issues with resistance and inadequate efficacy, particularly against pests like Chilo suppressalis, necessitating the development of new compounds with enhanced insecticidal activity.
Innovation Solution
A novel bisamide compound represented by general formula I, with specific substitutions for R1, R2, R3, and R4, is synthesized through reactions involving bromomethylcyclopropane and intermediates, offering improved insecticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing insecticides are used long-term and unreasonably, then initial insecticidal effects are achieved, but resistance problem becomes serious
Solution Approach 1:
The patent modifies the chemical structure of existing bisamide insecticides by changing parameters such as substituting different halogen atoms (F, Cl, Br, I) at specific positions on the benzamide ring, and varying the substituents on the cyclopropane ring. These parameter changes in molecular structure create new compounds with different biological properties that can overcome pest resistance while maintaining insecticidal activity
Solution Approach 2:
The invention creates composite molecular structures by combining a benzamide core with various substituted cyclopropane rings and heterocyclic groups. This composite approach generates diverse chemical entities within the bisamide class that can address resistance issues through structural complexity and multiple interaction modes with target pests
2Reliability
If existing insecticides are used, then some pest control is achieved, but insecticidal effects on Chilo suppressalis are unsatisfactory
Solution Approach 1:
The patent applies local quality changes by introducing specific substituents at particular positions on the molecular structure. For example, placing electron-withdrawing groups like CF3 or halogen atoms at specific ring positions creates localized electronic and steric effects that enhance binding affinity to the target pest's neural receptors, thereby improving activity against Chilo suppressalis
Solution Approach 2:
The invention introduces dynamic flexibility into the molecular structure through the cyclopropane ring with various substituents. This dynamic structural element allows the molecule to adapt its conformation to better fit the target binding site, enhancing insecticidal activity against difficult-to-control pests like Chilo suppressalis
Data Source
AI summary
This disclosure provides a bisamide compound and an application thereof, where the compound has a structure as shown by general formula I:the definition of each substituent in the formula is shown in the specification. The specification also discloses use thereof as an insecticide and an animal parasite control agent.