Bisphosphonate Bone Delivery via Mechanical Force

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Solution Overview

Problem

Current methods for delivering bisphosphonates and strontium ranelate near bone implants or prosthetics are limited in depth of penetration, leading to inadequate bone strengthening and potential side effects from systemic administration, with difficulty in controlling drug distribution.

Innovation Solution

A method involving a carrier composition of bisphosphonate and/or strontium ranelate combined with a mechanical force to deliver the compounds to a greater depth below the bone surface, using a bone graft material or cement, allowing for a larger bone volume influence and controlled distribution.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a bisphosphonate is delivered by painting it onto the bone or in combination with bone chips, then local delivery is achieved, but it is impossible to determine where the drug is delivered or the amount delivered to the bone because the distribution of the drug is impossible to control

Engineering Contradiction:

Improvelocal deliveryVSAvoiddrug distribution control

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

The patent pre-loads the bisphosphonate onto the implant surface before implantation, ensuring controlled distribution. The drug is applied to the implant in a controlled manufacturing process, allowing precise determination of drug location and amount before surgical implantation.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent uses an intermediary carrier substance (such as collagen, fibrin, or other biocompatible materials) to transport the bisphosphonate from the implant surface to the bone. This intermediary allows controlled release and distribution of the drug at the implant-bone interface.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of operation

If a bisphosphonate is combined with an apatite coating on an implant, then local delivery is achieved, but the depth of penetration is limited to a region very close to the bone implant interface (0 to 0.5 millimeters below the surface)

Engineering Contradiction:

Improvelocal deliveryVSAvoiddepth of penetration

Core Design Contradiction:

Ease of operationVSLength of stationary object

Solution Approach 1:

The patent employs hydraulic pressure or pneumatic force to drive the bisphosphonate solution deeper into the bone tissue. By applying controlled pressure during implantation, the drug can penetrate beyond the typical 0.5mm limit into deeper regions of the cancellous bone.

Inventive Principle:

Principle #29Pneumatics and hydraulics

Solution Approach 2:

The patent utilizes porous bone graft materials or scaffolds as a vehicle to deliver the bisphosphonate. These porous structures allow the drug to be distributed throughout the graft material and delivered deeper into the bone tissue as the graft integrates with the host bone.

Inventive Principle:

Principle #31Porous materials

3Reliability

If strontium ranelate is administered systemically, then bone deposition by osteoblasts is increased, but severe bone, muscle, and joint pain have been reported after systemic bisphosphonate treatment

Engineering Contradiction:

Improvebone strengthening effectVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies strontium ranelate locally at the implant site rather than systemically. By concentrating the drug at the specific location where bone formation is needed, the therapeutic effect is achieved while minimizing exposure to other tissues and reducing the risk of systemic side effects such as bone, muscle, and joint pain.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent uses a lower, localized dose of strontium ranelate at the implant site rather than a full systemic dose. This partial action is sufficient to stimulate bone formation at the implant-bone interface without causing the severe side effects associated with high-dose systemic administration.

Inventive Principle:

Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances bone strengthening by reducing osteoclast activity and increasing osteoblast deposition over a larger bone volume, reducing the risk of side effects associated with systemic administration and improving the effectiveness of bone implant integration.

Implementation Method 1

delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force

Methodology Applied

Scientific EffectMechanical force: Mechanical Force

Data Source

PatentUS8882740B2Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone

Publication Date: 2014.11.11 STRYKER EUROPEAN OPERATIONS HOLDINGS LLC

AI summary

A method for delivering a bisphosphonate and/or strontium ranelate below the surface of a bone using a mechanical force. The method includes the steps of combining a bisphosphonate and/or strontium ranelate with a carrier to form a delivery composition and delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force. Also provided is a method for strengthening a portion of a bone. This method includes the step of delivering an effective amount of a bisphosphonate and/or strontium ranelate below the surface of a portion of a bone with a mechanical force.