Black Ginger Polyalkoxyflavonoid Sirtuin Activator
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Solution Overview
Problem
Current sirtuin activators, such as resveratrol, are limited in availability and have weaker sirtuin activation activity, necessitating the development of a more potent and easily obtainable substance to effectively activate sirtuins for anti-aging, metabolic syndrome prevention, and other health benefits.
Innovation Solution
Black ginger or its extract, combined with polyalkoxyflavonoid compounds, serves as a sirtuin activator, exhibiting stronger activity than resveratrol, and is used in various formulations for metabolic syndrome prevention, anti-aging, and life-lengthening applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If resveratrol is used as a sirtuin activator, then sirtuin activation effect is achieved, but the activation strength is insufficient and availability is limited
Solution Approach 1:
The patent changes the chemical structure parameters of flavonoid compounds by introducing polyalkoxy groups at specific positions (5, 7, and 4') on the flavonoid backbone. This structural modification transforms ordinary flavonoids into polyalkoxyflavonoids with significantly enhanced sirtuin activation activity, achieving 10-fold or greater improvement over resveratrol while maintaining natural availability through black ginger extraction.
2Reliability
If natural sources like grape skin are used for resveratrol, then natural sirtuin activation is achieved, but the content is extremely low and costly
Solution Approach 1:
The patent extracts polyalkoxyflavonoid compounds from black ginger (Kaempferia parviflora) roots using solvent extraction methods. This extraction process isolates the active sirtuin-activating components from the plant material, providing a natural, cost-effective alternative to resveratrol with significantly higher availability and potency.
Solution Approach 2:
The patent creates structurally modified copies of natural flavonoids by introducing polyalkoxy groups, resulting in polyalkoxyflavonoids that replicate and enhance the sirtuin activation properties of natural compounds like resveratrol while being more abundantly available in black ginger.
3Ease of manufacture
If black ginger extract is used as sirtuin activator, then availability and cost are improved, but sirtuin activation activity needs to be enhanced
Solution Approach 1:
The patent creates composite polyalkoxyflavonoid structures by combining the flavonoid core structure with polyalkoxy side chains. This composite approach integrates the natural availability of black ginger extracts with enhanced sirtuin activation activity, achieving both affordability and potency through the synergistic combination of structural elements.
Data Source
AI summary
The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher:wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.