Automatic Blank Calibration with Reaction Chamber Stability Checks

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Solution Overview

Problem

Existing automatic analyzers do not confirm the device condition before implementing automatic blank calibration, which can lead to unsuitable conditions for absorbance measurement, compromising the accuracy of analysis results.

Innovation Solution

The automatic analyzer performs analysis preparation operations including reaction chamber temperature detection and other checks before executing automatic blank calibration to ensure a stable device condition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Extent of automation

If automatic blank calibration is implemented without confirming device condition, then automation extent and productivity are improved, but measurement precision and reliability deteriorate

Engineering Contradiction:
Improveautomatic blank calibrationVSAvoidabsorbance measurement accuracy
Core Design Contradiction:
Extent of automationVSMeasurement precision

Solution Approach 1:

The control unit executes analysis preparation operations including reaction chamber temperature detection before implementing automatic blank calibration. This preliminary check ensures the device is in a suitable condition for accurate absorbance measurement, resolving the contradiction by adding a preparatory step that maintains automation while ensuring measurement precision

Inventive Principle:
Principle #10Preliminary action

2Measurement precision

If analysis preparation operations are added before automatic blank calibration, then measurement precision and reliability are improved, but device complexity and time consumption increase

Engineering Contradiction:
Improveanalysis result accuracyVSAvoidoperation sequence complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent integrates temperature detection and other preparation operations into the automatic blank calibration sequence, ensuring measurements are performed under suitable conditions without requiring separate manual preparation steps, thus improving precision without significantly increasing operational complexity

Inventive Principle:
Principle #10Preliminary action

3Measurement precision

If analysis preparation operations are added before automatic blank calibration, then measurement precision is improved, but time consumption increases

Engineering Contradiction:
Improveanalysis result accuracyVSAvoidcalibration time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The control unit automatically executes analysis preparation operations including temperature detection before blank calibration without requiring manual intervention or waiting periods, ensuring measurement precision is maintained while minimizing additional time consumption through automated sequential execution

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach ensures that automatic blank calibration is performed only when the device is in a suitable condition, guaranteeing accurate analysis results and preventing calibration failures.

Implementation Method 1

a reaction chamber configured to control a temperature of the reaction vessel

Methodology Applied
Scientific EffectTemperature control: Heating

Implementation Method 2

an automatic analyzer measures a change over time in absorbance for a solution obtained by mixing a certain amount of a sample and a reagent

Methodology Applied
Scientific EffectAbsorbance measurement: Absorption Spectroscopy

Data Source

PatentEP4675281A1Automatic analysis device and automatic analysis method
Publication Date: 2026.01.07 HITACHI HIGH TECH CORP
  • EP4675281A1 patent drawingFigure 1
  • EP4675281A1 patent drawingFigure 2A
  • EP4675281A1 patent drawingFigure 2B

AI summary

The present disclosure proposes (see FIG. 3) an automatic analyzer that executes automatic blank calibration to ensure device performance when automatic blank calibration is implemented, and measures change over time in a mixture liquid obtained by mixing a specimen and a reagent, said automatic analyzer comprising a reaction vessel capable of accommodating the specimen and the reagent, an analysis unit that measures the mixture liquid accommodated in the reaction vessel, and a control unit, wherein the control unit executes analysis preparation operations including a reaction chamber temperature detection operation for performing temperature control of the reaction vessel, and other operations, and confirms that the condition of the automatic analyzer is stable, before executing the automatic blank calibration.