Blister Pack Dual-Seal Laminate for Multi-Drug Stability
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Solution Overview
Problem
Combining different pharmaceutical compositions in a single package is challenging due to potential chemical reactions and stability issues, leading to degradation of bioactive substances, and existing solutions require additional handling by patients, which can be inconvenient and error-prone.
Innovation Solution
A blister pack design featuring a base laminate with two distinct sealing subzones, one for a permanent seal and the other for a peelable seal, using a blend of polyethylene and functionalized ethylene copolymers to achieve different seal strengths without requiring different materials, allowing for separate storage and easy administration of multiple products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If different pharmaceutical compositions are packaged separately in different containers, then chemical stability and prevention of reactions is improved, but patient convenience and ease of operation deteriorates due to additional handling requirements
Solution Approach 1:
The package is segmented into multiple separate compartments or cavities within a single blister pack structure, allowing different pharmaceutical compositions to be physically isolated from each other to prevent chemical reactions, while still being part of the same package unit that the patient handles conveniently
Solution Approach 2:
Multiple separate containers that would otherwise need to be handled individually are merged into a single integrated blister pack structure, combining the benefits of separate storage for chemical stability with the convenience of a single package for patient use
2Ease of operation
If different pharmaceutical compositions are combined in a single package, then patient convenience and ease of operation is improved, but chemical stability deteriorates due to potential reactions and degradation of bioactive substances
Solution Approach 1:
The single package is divided into distinct compartments that physically separate different pharmaceutical compositions, preventing direct contact and chemical reactions while maintaining the convenience of a unified package structure for patient administration
Solution Approach 2:
A barrier or separator material is introduced between different pharmaceutical compositions within the single package, acting as an intermediary that prevents direct chemical interaction while allowing both substances to coexist in the same package unit
3Ease of manufacture
If a single sealing layer is used for the entire blister pack, then manufacturing simplicity is improved, but sealing precision deteriorates because uniform sealing strength cannot accommodate both permanent and peelable seal requirements
Solution Approach 1:
The sealing layer is designed with spatially varying properties, having different sealing strengths or compositions in different regions - a first sealing subzone with properties optimized for permanent seals and a second sealing subzone with properties optimized for peelable seals, allowing each zone to perform its specific function effectively
4Manufacturing precision
If different sealing materials are used to achieve different seal strengths, then sealing precision is improved, but device complexity increases due to the need for multiple sealing materials and processes
Solution Approach 1:
A composite sealing layer is used that combines multiple materials with different sealing properties into a single integrated layer, allowing different regions of the same sealing layer to exhibit different sealing strengths - one region providing permanent seal characteristics and another region providing peelable seal characteristics, thereby achieving precise sealing control without increasing overall device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The blister pack design enables safe storage and convenient administration of multiple pharmaceutical components by preventing direct contact and allowing controlled mixing of products, enhancing stability and adherence to medication regimens while simplifying patient handling.
Implementation Method 1
The sealing layer comprises a blend of polyethylene and of several functionalized ethylene copolymers
Implementation Method 2
a first sealing subzone that provides a permanent seal and a second sealing subzone that provides a peelable seal
Data Source
AI summary
The present invention relates to a blister pack that comprises a base laminate with a sealing layer and a lid laminate with a sealing layer, the base laminate having at least one cavity housing a product. The base laminate and the lid laminate are directly sealed to each other via their identical sealing layers whereby the seal comprises two different sealing subzones, a first sealing subzone providing a permanent seal and a second sealing subzone providing a peelable seal.