Multiday Blister Pack Up-Titration Dosage Forms

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing pharmaceutical dosage packages for up-titration processes are cumbersome due to the large number of dosage forms required, leading to complexity in ensuring proper medication consumption and potential patient confusion.

Innovation Solution

A multiday blister pack system where each cavity contains a single pharmaceutical dosage form with varying quantities of active ingredient, allowing for progressive dosing without the need for multiple dosage forms per day.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If multiple dosage forms are used to deliver progressively increasing dosages, then the up-titration process can be implemented, but the number of dosage forms increases, leading to larger blister pack size and increased complexity

Engineering Contradiction:

Improveup-titration capabilityVSAvoidblister pack complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

Each dosage form within the blister pack has a distinct local quality in terms of active ingredient quantity, allowing progressive dosing. The patent applies this by placing dosage forms with different dosages (e.g., 2.5mg, 5mg, 7.5mg, 10mg) in specific cavities, enabling up-titration without increasing the number of dosage forms per day.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The blister pack is segmented into multiple cavities, each containing a single dosage form with a specific dosage. This segmentation allows the patient to access only one dosage form per day, simplifying the up-titration process while maintaining the ability to progress through different dosage levels over time.

Inventive Principle:

Principle #1Segmentation

2Adaptability or versatility

If multiple dosage forms are used to deliver progressively increasing dosages, then the full dosage range can be provided, but patient confusion increases when assessing which dosage form to ingest on which day

Engineering Contradiction:

Improvedosage rangeVSAvoiddosage selection ease

Core Design Contradiction:

Adaptability or versatilityVSEase of operation

Solution Approach 1:

The patent employs color changes and visual differentiation of dosage forms based on size and color to help patients easily identify which dosage form to ingest on which day. Different cavity positions correspond to different days of the week, and the dosage forms are visually distinct, eliminating patient confusion while providing a full dosage range for up-titration.

Inventive Principle:

Principle #32Color changes

3Adaptability or versatility

If a large number of dosage forms are placed in the blister pack, then the complete up-titration regimen can be included, but the possibility of providing the dosage forms in a blister pack is foreclosed due to size constraints

Engineering Contradiction:

Improvecomplete dosing regimenVSAvoidblister pack area

Core Design Contradiction:

Adaptability or versatilityVSArea of stationary object

Solution Approach 1:

The complete dosing regimen is segmented across multiple cavities in a compact blister pack arrangement. Each cavity holds one dosage form, and the overall layout is optimized to fit within a manageable blister pack area, allowing the complete up-titration regimen to be provided without exceeding size constraints.

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS12201583B2Pharmaceutical dosage system

Publication Date: 2025.01.21 VANDA PHARMACEUTICALS INC

AI summary

A pharmaceutical dosage system includes a blister pack and a plurality of dosage forms contained by the blister pack. The dosage forms are to be consumed in an up-titration process. Only one single dosage form of the plurality of dosage forms is consumed on a given day throughout the up-titration process whereby dosages increase over the course of a multi-day period of time.