Blood Analysis Dilution Correction for Small Sample Precision
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Solution Overview
Problem
Existing blood analysis methods face challenges in achieving high repeatability and reproducibility when using small volumes of blood samples, particularly due to variations in dilution factors and contamination from kit components, leading to inaccurate measurement results.
Innovation Solution
A blood analysis method that corrects the dilution factor by calculating the concentration of normal components from the diluent solution and kit members, using sodium ions or chloride ions as homeostatic components to ensure accurate analysis of target components in small blood samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a small volume of blood sample is used for analysis, then the invasiveness of blood collection is reduced and patient comfort is improved, but the measurement precision and reliability of the analysis results deteriorate due to variations in dilution factors and contamination from kit components
Solution Approach 1:
The patent applies preliminary action by pre-calculating the concentration of normal components in the diluent solution and pre-determining correction values before the actual blood analysis. This allows the system to compensate for dilution factor variations and contamination effects in advance, ensuring measurement precision is maintained even when using small blood sample volumes
Solution Approach 2:
The patent employs parameter changes by dynamically adjusting the dilution factor based on the actual concentration of normal components detected in the blood sample. Instead of using a fixed dilution factor, the system modifies this parameter according to measured values, thereby compensating for variations and maintaining measurement accuracy with small sample volumes
2Productivity
If the dilution factor is not corrected for contamination from kit components, then the analysis process is simpler and faster, but the reliability of the measurement results deteriorates due to inaccurate concentration calculations
Solution Approach 1:
The patent applies preliminary action by pre-calculating correction values for contamination from kit components before the actual analysis. The concentration of normal components in the diluent solution is determined in advance, and correction factors are computed beforehand. This allows rapid correction during analysis without sacrificing reliability, as the computationally intensive pre-processing has already been completed
Solution Approach 2:
The patent implements feedback by measuring the actual concentration of normal components in the diluted blood sample and using this measured value to correct the dilution factor. The system continuously monitors and adjusts based on feedback from the measurement process, ensuring reliable results while maintaining efficient analysis throughput
Data Source
AI summary
An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including: a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing the diluent solution, a collection instrument for collecting the blood, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, and a second storing instrument for storing the recovered blood plasma, and in which the dilution factor is corrected after calculating in advance an amount of the normal component derived from the diluent solution, and/or an amount of the normal component derived from at least one of the members which may be contained in the diluent solution.