Blood Analyzer Dual Classification for White Blood Cell Count Accuracy
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Solution Overview
Problem
Blood analyzers often report pseudo-high values for white blood cell counts due to the presence of lipid particles and poorly hemolyzed red blood cells, which interfere with the accuracy of scattergram analysis.
Innovation Solution
The analyzer employs dual classification methods using first and second measurement data to distinguish between white blood cells and interfering particles, determining abnormal readings and outputting accurate counts by selecting between two measurement methods based on the data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single classification method is used to count white blood cells, then the device complexity is low, but measurement precision deteriorates due to interference from lipid particles and poorly hemolyzed red blood cells
Solution Approach 1:
The patent divides the white blood cell counting process into two separate classification methods: a first classification method that counts all particles in the white blood cell region, and a second classification method that specifically identifies and excludes lipid particles and poorly hemolyzed red blood cells. By segmenting the counting process into these two distinct classification pathways, the system achieves accurate white blood cell counts even in the presence of interfering particles, resolving the contradiction between measurement precision and device complexity.
2Reliability
If the scattergram includes all particles in the white blood cell region, then the measurement process is simple, but reliability deteriorates due to pseudo-high values from interfering particles
Solution Approach 1:
The patent extracts and identifies interfering particles (lipid particles and poorly hemolyzed red blood cells) from the white blood cell region of the scattergram using the second classification method. By specifically extracting these problematic particles and excluding them from the final count, the system eliminates the source of pseudo-high values and improves measurement reliability without requiring complex additional hardware.
3Measurement precision
If dual classification methods are implemented to distinguish white blood cells from interfering particles, then measurement precision improves, but processing time increases
Solution Approach 1:
The patent performs preliminary identification of interfering particles through the second classification method before finalizing the white blood cell count. By conducting this preliminary action of identifying lipid particles and poorly hemolyzed red blood cells in advance, the system can efficiently exclude them from the count without requiring repeated measurements or complex iterative processing, thus minimizing additional processing time while ensuring measurement accuracy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach prevents the reporting of pseudo-high white blood cell counts by accurately differentiating between actual white blood cells and lipid particles or poorly hemolyzed red blood cells, ensuring reliable blood cell analysis results.
Implementation Method 1
laser light is irradiated on the blood cells. The blood analyzer prepares a two dimensional distribution chart (scattergram) of the particles based on the forward scattered light and the lateral scattered light obtained by the irradiation with the laser light.
Data Source
AI summary
A blood analyzer configured to prevent an abnormal number of white blood cells caused by lipid particles or red blood cells of poor hemolysis from being output. The blood analyzer includes a system for obtaining a first white blood cell number and a system for obtaining a second white blood cell number. The analyzer also includes an output device for outputting the second white blood cell number, and a system for determining whether the second white blood cell number is abnormal. The output device is configured to output the first white blood cell number when the second white blood cell number has been determined to be abnormal.