Blood Analyzer Platelet Counting Control Method
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Solution Overview
Problem
Existing blood analyzers face challenges in consistently providing accurate platelet counts while minimizing analysis costs, as methods like fluorescent platelet counting require costly stain solutions and increase analysis processes.
Innovation Solution
A method to control blood analyzers by determining the relationship between electrical and optical measurement values from previous tests, selecting the appropriate detection method for current tests based on reliability, thereby optimizing the use of measurement samples and reducing unnecessary costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescent platelet counting (optical type measuring device) is used to ensure accurate platelet counts, then measurement precision is improved, but analysis cost increases due to required stain solutions
Solution Approach 1:
The system dynamically changes the measurement methodology parameter based on detected conditions. When platelet clumps are detected (condition change), the system switches from electrical resistance measurement to optical measurement with stain solution. When no clumps are present, it uses only electrical resistance measurement, avoiding unnecessary stain solution consumption while maintaining accuracy when needed.
Solution Approach 2:
The system performs preliminary detection of platelet clumps using electrical resistance measurement before deciding whether to proceed with optical measurement requiring stain solution. This preliminary action allows the system to anticipate when stain solution will be needed, preventing both unnecessary consumption and ensuring accuracy when clumps are present.
2Measurement precision
If both electrical resistance type and optical type measuring devices are used to differentiate red blood cells and platelets, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The system implements dynamic measurement methodology selection rather than continuously operating both measurement devices. Based on real-time detection of platelet clumps and particle distribution analysis, the system dynamically switches between electrical resistance-only mode and combined optical-electrical resistance mode, reducing operational complexity while maintaining differentiation accuracy when needed.
Solution Approach 2:
The system extracts and applies only the necessary measurement method based on detected conditions. When platelet clumps are absent, the system extracts and uses only electrical resistance measurement, avoiding the complexity of optical measurement. When clumps are detected, it extracts and applies optical measurement with stain solution, achieving differentiation accuracy only when necessary.
3Measurement precision
If optical type measuring device is used for all platelet measurements, then measurement precision is improved, but analysis cost increases due to stain solution requirements
Solution Approach 1:
The system uses the inexpensive electrical resistance measurement method as the primary, routine approach for platelet counting. This cheap method is used for all samples initially, with optical measurement requiring stain solution reserved only for cases where platelet clumps are detected. This strategy treats the expensive optical measurement as a selective supplement rather than a universal requirement, dramatically reducing stain solution consumption while maintaining reliability when needed.
Solution Approach 2:
Instead of applying optical measurement with stain solution to all samples (excessive action), the system applies it partially only to samples where platelet clumps are detected. This partial action approach ensures measurement precision is improved only where necessary, avoiding unnecessary stain solution usage on samples that can be accurately measured by electrical resistance alone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures consistent and accurate platelet count monitoring by selecting the most reliable detection method, reducing the need for costly optical measurements and minimizing additional analysis processes.
Implementation Method 1
red blood cells and platelets are measured by using an electrical resistance type measuring device
Implementation Method 2
an optical measuring device... adopts more reliable platelet number between a platelet number by the electrical resistance type measuring device and a platelet number by the optical measuring device
Data Source
AI summary
A method of controlling a blood analyzer for measuring platelets is provided. The method comprises: determining a relationship between at least one first measurement value obtained by detecting platelets in at least one previous test by an electrical type detector of the blood analyzer and at least one second measurement value obtained by detecting the platelets in the at least one previous test by an optical type detector of the blood analyzer, and controlling the blood analyzer to prepare the first and/or second measurement sample for a current test according to the determined relationship.