Blood Analyzer Wavelength Selection for Coagulation Interference
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Solution Overview
Problem
Conventional blood coagulation analyzers face challenges in accurately measuring blood coagulation factors due to interference substances like hemoglobin, bilirubin, and chyle, which affect optical measurements, especially when the coagulation factor content is low, leading to reduced analysis accuracy at long wavelengths and varying optimal measurement wavelengths depending on the sample.
Innovation Solution
A blood analyzer that emits light at multiple wavelengths to a blood specimen-reagent mixture, receives and stores data on light transmission changes over time, and selects the appropriate wavelength for analysis based on these changes to minimize interference from substances like hemoglobin, bilirubin, and chyle, allowing for precise measurement of blood coagulation characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If long wavelength light (e.g., 800 nm) is used for measurement, then interference from hemoglobin and bilirubin is reduced, but measurement sensitivity decreases
Solution Approach 1:
The patent applies parameter changes by dynamically selecting the measurement wavelength based on the sample's characteristics. The system evaluates multiple wavelengths (including both long wavelength like 800 nm for reduced interference and shorter wavelengths for higher sensitivity) and selects the optimal wavelength for each measurement, thereby resolving the contradiction between reducing interference and maintaining sensitivity
Solution Approach 2:
The patent implements dynamics by making the measurement wavelength adjustable and selectable rather than fixed. The system can dynamically switch between different wavelengths depending on the sample conditions, allowing optimal performance across varying sample types with different interference substance concentrations
2Measurement precision
If light at wavelength near 660 nm is used for measurement, then suitable sensitivity is obtained, but interference substances still affect the measurement
Solution Approach 1:
The patent changes the wavelength parameter dynamically based on sample conditions. Rather than being fixed at 660 nm, the system evaluates multiple wavelengths and selects the one that provides both adequate sensitivity and minimal interference for each specific sample
Solution Approach 2:
The measurement system becomes dynamic by allowing wavelength selection based on real-time sample assessment. The system can adapt the measurement wavelength to match sample characteristics, transitioning from a static 660 nm fixed wavelength to a flexible multi-wavelength selection approach
3Device complexity
If a fixed measurement wavelength is used, then the device structure is simple, but analysis accuracy varies with different sample types
Solution Approach 1:
The patent applies universality by designing a measurement system that can handle multiple sample types with different characteristics using a single device. The system incorporates multiple wavelength capabilities and automated selection logic, making it universally applicable to various samples while maintaining accuracy across all sample types
Solution Approach 2:
The system changes the wavelength parameter based on sample type and interference characteristics. By incorporating multiple wavelength options and automated selection, the device maintains structural relative simplicity while achieving high accuracy across diverse sample types through intelligent parameter adjustment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables accurate analysis of blood coagulation by selecting the most suitable wavelength for each sample, reducing interference and enhancing measurement sensitivity, thereby improving the precision of coagulation time measurements and fibrinogen content analysis.
Implementation Method 1
optically measuring the process of a coagulation reaction in the analysis sample
Data Source
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AI summary
A blood analyzer has a light emitter for emitting light to an analysis sample which is a mixture of a blood specimen and a reagent. It also has a light receiver for receiving light of a plurality of wavelengths from the analysis sample over time, and for acquiring data of the amount of the received light corresponding to each of the wavelengths at a plurality of points of time. A selector selects the data corresponding to one of the wavelengths, based on the change of the amount of received light over time in the data acquired by the light receiver. An analysis section analyzes a characteristic of the blood specimen using the data which are selected by the selector. A blood analyzing method is also described.