Blood Bag System for Low Plasma Platelet Preparation
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Solution Overview
Problem
Current methods for preparing washed platelets during transfusion often result in insufficient reduction of blood plasma content, as a significant amount of plasma remains in the buffy coat component after centrifugation, making it challenging to obtain a platelet preparation with a low plasma content efficiently.
Innovation Solution
A blood bag system and method that involves centrifuging whole blood into light, medium, and heavy specific gravity components, using transfer tubes to separate and process these components, and an added solution to discharge residual plasma from the medium specific gravity component, thereby obtaining a washed medium specific gravity blood component with a low plasma content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If centrifugation is performed to separate blood components, then blood plasma and red cell concentrates are separated, but a considerable amount of blood plasma remains in the buffy coat
Solution Approach 1:
The invention extracts the harmful component (blood plasma) from the buffy coat by adding a platelet added solution that replaces the blood plasma. The platelet added solution is added to the buffy coat, and through centrifugation, the blood plasma is separated and removed, leaving the buffy coat with reduced plasma content.
Solution Approach 2:
The invention changes the physical-chemical parameters of the buffy coat by adding the platelet added solution, which has different density and composition characteristics. This parameter change enables the replacement of blood plasma and achieves the desired low plasma content in the final washed platelet product.
2Manufacturing precision
If multiple transfer tubes and bags are used to separate blood components, then component separation is achieved, but the system complexity increases
Solution Approach 1:
The invention makes the first bag serve multiple functions: it is used for initial blood collection, then for buffy coat pooling after centrifugation, and finally for the washing process. This multi-functional use of the same bag reduces the total number of bags and tubes needed in the system.
Solution Approach 2:
The invention combines the buffy coat pooling step with the washing step by using the same first bag for both operations. Instead of transferring buffy coat to a separate pooling bag and then to a washing bag, the process is merged into a single bag system, reducing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach securely and efficiently achieves a medium specific gravity blood component with a sufficiently low content of light specific gravity blood, reducing plasma content in platelet preparations and facilitating the production of washed platelets with lower plasma levels.
Implementation Method 1
a centrifugal force acts in a transfer completed state in which the two blood components are separately transferred to the second bag and the third bag, respectively
Implementation Method 2
centrifuging whole blood or a blood component into a light specific gravity blood component, a medium specific gravity blood component, and a heavy specific gravity blood component
Implementation Method 3
the added solution is transferred from the fourth bag to the bag accommodating the medium specific gravity blood component through the third transfer tube, thereby discharging the light specific gravity blood component remaining in the medium specific gravity blood component to an outside of the bag
Data Source
AI summary
Provided are a blood bag system and a blood treatment method capable of securely and efficiently obtaining a medium specific gravity blood component having a sufficiently low content rate of a light specific gravity blood component.In a blood bag system (10) used for a blood treatment method, in a transfer completed state in which whole blood in a first bag (12) is centrifuged to transfer blood plasma to a second bag (14) through a first transfer tube (24) and transfer red cell concentrates to a third bag (16) through a second transfer tube (26), a buffy coat is left in the first bag (12). In the transfer completed state, when a platelet added solution is transferred from a fourth bag (18) to the first bag (12) on which a centrifugal force acts through a third transfer tube (28), blood plasma in the buffy coat is discharged from the first bag (12).