Blood Cell Analyzer Aging Detection via Scattergram Analysis
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Solution Overview
Problem
Blood samples stored for extended periods undergo changes that affect the accuracy of cell distribution information detected by blood cell analyzers, leading to potential inaccuracies in diagnosis and screening.
Innovation Solution
A method and device that analyze optical signal values from blood samples to identify an 'aging characteristic region' in scattergrams, determining if a sample is aged by assessing cell distribution information, and correcting cell parameters based on this information to ensure accurate detection results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blood samples are stored for extended periods for reexamination and error correction, then the opportunity for reexamination is provided, but the cell parameters change significantly and detection accuracy deteriorates
Solution Approach 1:
The patent applies preliminary action by detecting cell distribution information in advance to identify aged samples before final analysis. The system performs preliminary detection of cell distribution characteristics (such as neutrophil distribution) to determine sample aging status, allowing users to take corrective actions like recollecting samples before making final diagnostic decisions, thus preventing inaccurate results from aged samples
Solution Approach 2:
The patent implements feedback by using detected cell distribution information to provide feedback on sample quality status. The system continuously monitors cell distribution parameters and provides feedback indicators (such as aging assessment results) to guide whether the sample is suitable for analysis or needs to be recollected, enabling dynamic adjustment of detection strategies based on real-time sample status
2Adaptability or versatility
If blood samples are transported to central laboratories for detection, then centralized testing is achieved, but transportation time increases and sample aging occurs
Solution Approach 1:
The patent applies preliminary action by performing aging assessment at the point of collection or during transport preparation. The system detects cell distribution information early in the process to identify samples that are already showing signs of aging, allowing for timely intervention such as prioritizing transport or notifying the central laboratory to perform urgent analysis upon receipt, thereby compensating for the time loss during transportation
3Measurement precision
If cell distribution information is analyzed to identify aged samples, then detection accuracy is improved, but additional detection steps are required
Solution Approach 1:
The patent applies universality by designing the cell distribution detection system to serve multiple functions. The same optical detection channels and data processing systems used for routine cell counting and differential analysis are also utilized to detect aging-related distribution patterns. This multi-functional approach allows the system to perform both routine hematological analysis and aging assessment without requiring entirely separate detection equipment, thereby limiting the increase in device complexity
Solution Approach 2:
The patent applies parameter changes by focusing on specific cell distribution parameters (such as neutrophil distribution width, skewness, or position in scattergrams) that change characteristically with sample aging. By monitoring these specific parameters rather than all cell parameters, the system achieves effective aging detection with minimal additional complexity, as these parameter changes can be extracted from existing detection data through additional analysis steps
Data Source
AI summary
Disclosed are a method for detecting a blood sample, a blood cell analyzer, and a storage medium. The method includes: acquiring at least two types of optical signal values of cells in a sample from a target detection channel, and generating a scattergram or a data array according to the at least two types of optical signal values of the cells; detecting cell distribution information of an aging characteristic region in the scattergram or data array; and outputting a detection result according to the cell distribution information.