Blood Cell Analyzer Dual Detection Histograms
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Solution Overview
Problem
Current blood cell analyzers struggle to accurately distinguish between different types of anemia, such as iron deficiency anemia and β thalassemia, due to overlapping characteristics, making it difficult to determine the precise treatment.
Innovation Solution
A blood cell analyzer equipped with both electrical and optical detection units that generate histograms from volume and scattered light intensity information of red blood cells, allowing for the differentiation between types of anemia by displaying these histograms alongside each other for clear comparison.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional blood cell analyzers use only electrical detection for red blood cell analysis, then the device complexity is low and cost is reduced, but the measurement precision for distinguishing anemia types is insufficient
Solution Approach 1:
The patent combines electrical detection (impedance method) and optical detection (light scattering method) into a single blood cell analyzer system. The electrical detection unit measures cell volume through impedance changes, while the optical detection unit measures light scattering intensity and angle. By merging these two detection methods, the system achieves comprehensive characterization of red blood cells, enabling accurate differentiation between iron deficiency anemia and beta-thalassemia through comparative analysis of both electrical and optical parameters.
2Measurement precision
If multiple separate examinations are performed to diagnose anemia types, then the measurement precision improves, but the loss of time and examination cost increase
Solution Approach 1:
The patent makes the blood cell analyzer multi-functional by equipping it with both electrical and optical detection capabilities within a single device. This universal system can perform multiple functions: electrical impedance measurement for cell volume, optical light scattering measurement for cell morphology, and integrated analysis for anemia type differentiation. By consolidating these functions into one device, the system eliminates the need for multiple separate examinations, reducing both time loss and examination costs while maintaining high diagnostic accuracy.
3Reliability
If only electrical detection is used for red blood cell analysis, then the device cost is low, but the reliability of anemia type identification is insufficient
Solution Approach 1:
The patent introduces optical detection as an intermediary measurement method that complements electrical detection. The optical detection unit measures light scattering intensity and angular distribution, providing intermediate information about red blood cell morphology and hemoglobin content. This intermediary optical measurement bridges the gap between simple electrical impedance data and complex diagnostic requirements, enhancing the reliability of anemia type identification without requiring overly complex detection systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate identification and differentiation of anemia types, providing useful diagnostic information at a lower cost without the need for additional examinations, facilitating early and appropriate treatment.
Implementation Method 1
a first detection unit for electrically detecting blood cells in blood sample
Implementation Method 2
a second detection unit for optically detecting blood cells in blood sample
Data Source
AI summary
A blood cell analyzer is provided with a first detection unit for electrically detecting blood cells in blood sample; a second detection unit for optically detecting blood cells in blood sample; a volume information obtainer for obtaining volume information of red blood cells based on the electrically detected blood cells; a scattered light intensity information obtainer for obtaining a scattered light intensity of red blood cells based on the optically detected blood cells; a first histogram preparer for preparing a first histogram of the volume information of each of red blood cells; a second histogram preparer for preparing a second histogram of the scattered light intensity information of each of red blood cells; a display unit; and a data processor for preparing a screen for displaying on the display unit, the screen including the first and second histograms.