Blood Cell Morphology Tracking via Narrow Forward Scattered Light
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Solution Overview
Problem
Current health monitoring systems lack a reliable and sensitive method for early detection of morphological changes in blood cells, which can indicate changes in health and robustness.
Innovation Solution
A system and method utilizing narrow forward scattered light to track morphological changes in blood cells through a tracking value calculated from first and second scattered light intensity angular distributions, detected using a forward scattered light detector and a processor, with a configuration including an incident light source, sample container, and specific detection parameters to assess the effect of challenge agents on blood samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional light scattering methods are used to detect blood cell morphological changes, then the system can monitor blood cells, but the detection sensitivity and reliability are insufficient for early warning of health changes
Solution Approach 1:
The patent focuses detection on a specific local region - the narrow forward scattering angle range (0-4 degrees, preferably 0-2 degrees). By concentrating measurement resources on this particular angular region where morphological changes produce characteristic scattering patterns, the system achieves higher detection sensitivity and reliability for early health warning without requiring full-sphere detection.
2Loss of information
If scattered light intensity is measured over a wide angular range, then more comprehensive data is obtained, but the complexity of the detection system and data processing increases
Solution Approach 1:
The patent extracts only the essential and most informative portion of the scattering data - specifically the narrow forward scattering angles (0-4 degrees). By taking out just this critical angular range rather than measuring the complete scattering pattern, the system maintains sufficient information for detecting morphological changes while significantly reducing detector complexity, data volume, and processing requirements.
3Measurement precision
If multiple scattered light intensity measurements at different angles are performed, then morphological changes can be tracked, but the measurement time and processing complexity increase
Solution Approach 1:
The patent applies partial action by measuring scattered light intensity at multiple discrete angles within the narrow forward range (0-4 degrees) rather than performing continuous angular scanning. This approach provides sufficient tracking accuracy for morphological changes by sampling key angular positions, while dramatically reducing measurement time and processing complexity compared to exhaustive angular coverage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides a sensitive, reliable, and early warning of changes in health and robustness by accurately tracking morphological changes in blood cells, enabling timely interventions and improved diagnostic capabilities.
Implementation Method 1
Passage of the light through the sample container produces a forward scattered light angular range away from the incident light central axis
Data Source
AI summary
Early warning of changing health and robustness is given by tracking of ease of morphological changes in blood cells obtained by comparing intensities in a first scattered light intensity angular distribution and intensities in a second scattered light intensity angular distribution, with the light being scattered by blood cells into very narrowly forward scattered light intensity angular range.