Blood Cell Analyzer Pulse Width Correction for Aggregation

The patent segments the particle counting process into multiple stages: initial particle detection, pulse width analysis, aggregation identification, and correction calculation. By dividing the counting process into distinct segments with specific functions, the system achieves high measurement precision while maintaining manageable complexity through modular processing steps.

The patent performs preliminary action by analyzing pulse width information before final particle counting. The system pre-identifies aggregated particles by examining pulse width characteristics, then applies correction coefficients in advance to adjust the counting results. This preliminary analysis prevents aggregation errors from propagating through the entire counting process.

The patent replaces mechanical re-counting or physical re-sampling with an electronic correction system. Instead of physically separating aggregated particles or re-collecting samples, the system uses pulse width signal analysis and mathematical correction coefficients to compensate for aggregation effects. This substitution of electronic processing for mechanical operations maintains high precision while minimizing time loss.

The patent introduces pulse width information as an intermediary parameter between particle detection and final counting. This intermediary provides aggregation state information without requiring additional physical measurements or time-consuming operations. The pulse width serves as a efficient mediator that enables correction calculations to be performed rapidly based on existing signal characteristics.

The patent implements self-service by using the pulse width information that is already generated during normal particle detection. The system does not require separate dedicated sensors or additional signal generation equipment - it utilizes the existing pulse width data from the flow cytometry process itself. This self-service approach enables aggregation detection without adding significant device complexity.

The patent applies universality by making the pulse width analysis serve multiple functions: it characterizes particle size, identifies aggregation states, and provides correction factors all from a single measurement parameter. This multi-functionality eliminates the need for separate detection systems for each function, thereby maintaining device simplicity while achieving high measurement precision through comprehensive use of existing signal data.