Blood Circuit Cooling Water Circulation for Photodynamic Therapy
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Solution Overview
Problem
Photodynamic therapy devices cause an increase in blood temperature due to irradiation light, which can burden the patient's body and adversely affect the blood itself.
Innovation Solution
A photodynamic therapy device with a cooling water circulation unit that includes a circuit cooling block and an irradiation unit, where a cooling water circulation unit is connected to the circuit cooling block to suppress temperature rise by cooling the blood tube and blood through thermal conductivity and water flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blood is irradiated with light beam by LED at the time of PDT treatment, then photodynamic therapy effect is achieved, but blood temperature rises and places burden on patient's body
Solution Approach 1:
A heat exchanger is introduced as an intermediary component between the blood circulation system and the cooling water circulation system. The heat exchanger enables thermal energy transfer from blood to cooling water without direct contact between the two fluids, effectively mediating the temperature control function while maintaining system separation and preventing contamination
Solution Approach 2:
The heat generation problem is addressed by extracting thermal energy from the blood through the heat exchanger and transferring it to the cooling water system. This separation of heat extraction from the main treatment process allows continuous photodynamic therapy while actively removing excess heat
2Temperature
If cooling water circulation unit is added to suppress temperature rise, then blood temperature is controlled, but device complexity increases
Solution Approach 1:
The cooling water circulation unit is designed to serve multiple functions: it cools the blood through the heat exchanger, maintains a reservoir of cooled water for continuous temperature control, and can be integrated with the existing blood circulation system. This multi-functionality reduces the need for separate cooling systems and minimizes overall device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively suppresses the temperature rise of blood during photodynamic therapy, maintaining it below 40°C by utilizing a cooling mechanism that includes a circuit cooling block and a cooling water circulation unit.
Implementation Method 1
a cooling water circulation unit is connected to the circuit cooling block to suppress temperature rise by cooling the blood tube and blood through thermal conductivity
Implementation Method 2
cooling the blood tube and blood through thermal conductivity and water flow
Data Source
Figure 1A
Figure 1B
Figure 2A
AI summary
The photodynamic therapy device of the present disclosure is a photodynamic therapy device that irradiates light from a light source onto blood that has been taken out of a patient's body and is flowing in the blood tube, the blood having absorbed a photoreactive agent, to destroy an undesirable component in the blood or affect the component. The photodynamic therapy device includes the irradiation unit that includes a light source and irradiates the blood in the blood tube with light, and the circuit cooling block that cools the blood in the blood tube. The circuit cooling block is connected to the pump that circulates cooling water in the circuit cooling block, the reservoir tank, and the cooling unit that cools water by the water flow path for flowing the cooling water.