Blood Coagulation Time Analysis Without Plasma Mixing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for analyzing the cause of prolonged coagulation time in blood specimens require the preparation and mixing of subject and normal plasmas, leading to complex and cumbersome work processes.
Innovation Solution
A system and method that analyzes the cause of prolonged coagulation time without the need for mixing subject and normal plasmas, using an analyzer and measurement device to measure coagulation times under different incubation conditions and analyze coagulation waveforms to determine the cause.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If cross-mixing test with mixed plasmas is used to analyze cause of prolonged coagulation time, then cause analysis can be performed, but preparation work becomes complicated and cumbersome
Solution Approach 1:
The invention extracts the essential analytical function from the complex cross-mixing test by using only the subject's plasma. The cause analysis is achieved by comparing coagulation times at different incubation temperatures without needing to mix with normal plasma, thereby eliminating the complicated preparation steps while maintaining diagnostic capability
Solution Approach 2:
The invention creates a simplified analytical model that copies the diagnostic purpose of the cross-mixing test but eliminates the need for physical mixing. By using computational comparison of coagulation curves at different temperatures, it replicates the cause-analysis function without requiring mixed plasma samples
2Reliability
If mixed plasma preparation is required, then cause analysis can be performed, but work process becomes complicated
Solution Approach 1:
The subject's plasma alone provides sufficient information for cause analysis when tested at different incubation temperatures. The plasma itself contains all necessary coagulation factors and abnormalities that can be detected through temperature-varied coagulation time measurement, eliminating the need for external normal plasma supplementation
Data Source
Figure 1
Figure 2
Figure 3
AI summary
Disclosed is a method for analyzing a cause of prolonging a coagulation time of a blood specimen, the method comprising: adding a calcium solution to a first sample resulting from an elapse of a first waiting time from mixing of a blood specimen from a subject and a measurement reagent for an activated partial thromboplastin time; obtaining a first coagulation time and/or a first parameter regarding a differential of a coagulation waveform, for the first sample to which the calcium solution has been added; adding the calcium solution to a second sample resulting from an elapse of a second waiting time, which is longer than the first waiting time, from mixing of the blood specimen from the subject and the measurement reagent; obtaining a second coagulation time and/or a second parameter regarding a differential of a coagulation waveform, for the second sample to which the calcium solution has been added; and obtaining information regarding a cause of prolonging a coagulation time, on the basis of the first coagulation time and/or the first parameter and the second coagulation time and/or the second parameter.