Blood Coagulation Analysis Using Rt Ratio to Detect Early Reaction Errors
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Solution Overview
Problem
Existing blood coagulation tests suffer from early reaction errors (ER) that cause erroneous detection of coagulation time, leading to inaccurate analysis and reduced analytical efficiency when measuring multiple specimens.
Innovation Solution
A method that distinguishes early reaction errors from true coagulation reactions by monitoring the ratio of coagulation reaction points (Rt) and accumulated ratios (Z) in real time, allowing accurate detection of the coagulation end point and time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a longer measurement time is set to allow measurement until the end of coagulation reaction for abnormal specimens, then the coagulation reaction can be fully measured for all specimens, but the analytical efficiency decreases because most specimens are normal and do not require extended measurement
Solution Approach 1:
The measurement time is made dynamic rather than fixed. The system automatically adjusts the measurement duration based on the actual coagulation reaction progress of each specimen, extending measurement only when necessary for abnormal specimens while allowing early termination for normal specimens, thus resolving the contradiction between measurement completeness and analytical efficiency
Solution Approach 2:
The system continuously monitors the coagulation reaction in real-time and uses this feedback to determine when to terminate measurement. By detecting the end of coagulation reaction dynamically, the system avoids unnecessary extended measurement for normal specimens while ensuring complete measurement for abnormal specimens, balancing reliability and productivity
2Measurement precision
If noise reduction methods are applied to eliminate early reaction errors, then the measurement precision improves, but the device complexity and analysis process become more complicated
Solution Approach 1:
The system extracts and identifies the early reaction error component from the total coagulation reaction curve by detecting characteristic patterns. By separating the erroneous early reaction portion from the true coagulation reaction, the system can accurately determine coagulation time without being affected by noise, improving measurement precision without requiring complex additional hardware
Solution Approach 2:
The system replaces complex physical noise filtering mechanisms with computational analysis methods. By using algorithms to detect and correct early reaction errors in the measured data, the system achieves noise reduction and improved precision through software-based solutions rather than adding complex mechanical or physical filtering components
Data Source
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AI summary
A method for analyzing a blood coagulation reaction includes: (1) acquiring P(i) which is a blood coagulation reaction of a blood specimen, where i is a variable indicating the number of measurement points or time; (2) acquiring t1 and t2 from the P(i), where both t1 and t2 represent the number of measurement points or time, t1 = i, and t2 < t1, and t1 and t2 satisfy an equation: P(t2) = P(t1) × X%, where the P(t1) and the P(t2) respectively represent blood coagulation reactions of the blood specimen at t1 and t2, and X ranges from 20 to 70; and (3) acquiring Rt which represents a ratio of t1 to t2.