Blood Coagulation Analyzer Scattered Light Correction
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Solution Overview
Problem
Automatic blood coagulation analysis devices face reduced measurement precision when using multiple scattered light measurement units due to individual differences in light intensity, distance, and sensor placement, affecting the consistency of fibrinogen concentration measurements across specimens.
Innovation Solution
The device incorporates a correction coefficient holding unit and an Fbg computation module that corrects measured values using specific coefficients for each scattered light measurement unit, ensuring consistent results across multiple units by accounting for individual differences.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If multiple scattered light measurement units are used to simultaneously measure multiple specimens, then analysis efficiency is improved, but measurement precision deteriorates due to individual differences among measurement units
Solution Approach 1:
The patent applies parameter changes by introducing correction coefficients that modify the measured scattered light intensity values. Each measurement unit has its specific correction coefficient stored in the correction coefficient holding unit, which compensates for individual differences in light intensity, distance, and sensor placement. This allows multiple measurement units to produce consistent results despite their physical variations.
Solution Approach 2:
The correction coefficient acts as an intermediary between the scattered light measurement units and the final measurement results. The correction coefficient holding unit stores these intermediary values, and the Fbg computation module uses them to adjust raw measurements, thereby mediating the individual differences among measurement units and achieving consistent precision across all units.
2Productivity
If multiple scattered light measurement units are used, then the ability to simultaneously measure multiple specimens is improved, but variability of measured values increases
Solution Approach 1:
The patent stabilizes measured values by applying correction coefficients that adjust for individual unit variations. The correction coefficient holding unit maintains these parameters, and the Fbg computation module uses them to normalize measurements from different units, reducing variability and ensuring consistent results across simultaneous measurements.
Solution Approach 2:
The system implements feedback by storing correction coefficients for each measurement unit and applying them to compensate for individual differences. This feedback mechanism ensures that variations in light intensity, distance, and sensor placement are corrected, maintaining stability in measured values across multiple simultaneous measurements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the precision and efficiency of fibrinogen concentration measurements by reducing variability among scattered light measurement units, allowing for accurate determination of fibrinogen levels in multiple specimens.
Implementation Method 1
irradiating the reaction solution with light, and measuring scattered light. When PT reagent is added to the specimen, as the final reaction, the fibrinogen within the specimen changes to fibrin. Fibrinogen is soluble in water, and hardly scatters any light when irradiated with light, while fibrin is insoluble in water and produces scattering when irradiated with light.
Data Source
AI summary
An automatic blood coagulation analysis device including a computation processing unit which executes computation processing according to a pre-installed program, and a storage unit which stores data acquired from outside and data obtained through computation processing by the computation processing unit. The computation processing unit comprises an Fbg computation module, a correction coefficient computation module, a reference value setting module and a difference module. The storage unit comprises a standard sample measured value holding unit, base value holding unit, standard sample difference value holding unit, reference value holding unit, correction coefficient holding unit, specimen measured value holding unit and specimen difference value holding unit.