Blood Coagulation Testing Device with Anticoagulant Neutralization
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Solution Overview
Problem
Existing PT/APTT/FIB/TT assay systems cannot directly test anticoagulated blood samples, as the anticoagulant hinders the clotting process, necessitating a method to neutralize the anticoagulant effect without impacting the blood's inherent coagulation properties.
Innovation Solution
An apparatus with a blood preprocessing unit that uses a filter material or soluble calcium salt to remove or neutralize the anticoagulant effect, allowing the blood to clot and enabling the measurement of coagulation indicators like Prothrombin Time, Activated Partial Thromboplastin Time, Fibrinogen Content, and Thrombin Time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If anticoagulant is added to blood sample, then blood sample can be stored and transported without cloting, but the anticoagulant hinders the clotting process and prevents direct testing on existing meters
Solution Approach 1:
The patent introduces a preprocessing unit as an intermediary component between the anticoagulated blood sample and the testing meter. This unit contains reagents that neutralize the anticoagulant effect, allowing the blood to clot properly for testing while maintaining the benefit of having collected anticoagulated blood samples for storage and transport
Solution Approach 2:
The patent applies preliminary action by performing anticoagulation neutralization before the actual coagulation testing. The preprocessing unit prepares the blood sample in advance by removing or neutralizing the anticoagulant effect, so that when the blood enters the reacting unit, it can undergo normal coagulation process for accurate measurement
2Measurement precision
If existing PT/APTT/FIB/TT assay systems are used, then coagulation indicators can be measured, but the systems cannot directly test anticoagulated blood samples
Solution Approach 1:
The patent enhances the universality of the testing system by integrating a preprocessing unit that can handle both anticoagulated and non-anticoagulated blood samples. The system becomes versatile enough to process various blood sample types directly, eliminating the need for separate processing procedures for different sample conditions
Solution Approach 2:
The preprocessing unit performs preliminary neutralization of the anticoagulant effect before the blood sample reaches the reacting unit. This preliminary action ensures that the subsequent coagulation measurement process proceeds normally, allowing accurate measurement of coagulation indicators in anticoagulated blood samples
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the direct testing of anticoagulated blood samples by restoring their coagulation properties, allowing accurate measurement of coagulation indicators with minimal deviation from fresh blood results, thus overcoming the limitations of existing systems.
Implementation Method 1
the blood preprocessing part is configured to remove or neutralize the anticoagulation effect of the anticoagulant (particularly artificially added) existed in the blood sample
Implementation Method 2
the reacting unit includes a module for applying a voltage difference to the blood sample and recording electrical signals
Data Source
AI summary
Disclosed is an apparatus for testing blood coagulation indicators, including a blood sample receiving and preprocessing unit, and the blood preprocessing part is configured to remove or neutralize the anticoagulation effect of the artificially added anticoagulant in the blood sample; a reacting unit in which the blood undergoes a clotting process; a blood coagulation indicator analyzing and computing unit which may measure an electrical signal passing through the blood sample during the course of testing to obtain measurement results reflecting a time measurement function; and a result displaying unit. Further disclosed is a method for testing coagulation indicators of a blood sample using the apparatus.