Blood Coagulation Timing from Weighted Velocity Waveforms
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for measuring blood coagulation time in automated analyzers face challenges in accurately determining coagulation times for abnormal samples due to varied reaction curves and noise interference, leading to inefficiencies in analysis time and reliability.
Innovation Solution
A method involving the calculation of weighted average time from a specific calculation target area of the coagulation velocity waveform, using first-order differential curves, to determine coagulation time, which is less susceptible to noise and abnormal curve shapes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the percentage method is used to calculate coagulation time, then accurate measurement of coagulation time is achieved, but the analysis time becomes excessively long for abnormal samples
Solution Approach 1:
The patent divides the coagulation reaction curve into multiple segments with different calculation methods. For normal samples, the percentage method is used for accurate measurement. For abnormal samples showing low coagulability, the patent identifies alternative calculation points (such as the inflection point or specific time points) to determine coagulation time without requiring measurement until the maximum scattered light is reached, thereby reducing analysis time while maintaining accuracy.
2Productivity
If the differentiation method is used to calculate coagulation time, then faster analysis is achieved, but accurate measurement fails for abnormal samples with low coagulability
Solution Approach 1:
The patent changes the calculation parameter from the peak of the differential curve (which may be absent or multiple in abnormal samples) to alternative parameters such as the inflection point of the coagulation curve or specific time points where the scattered light reaches predetermined thresholds. This parameter change allows accurate coagulation time measurement for both normal and abnormal samples while maintaining fast analysis speed.
3Loss of information
If photometric data is collected continuously, then complete coagulation reaction information is obtained, but noise interference increases and false detection occurs
Solution Approach 1:
The patent extracts only the essential information needed for accurate coagulation time measurement from the continuous photometric data. Instead of using all collected data points, the method identifies and uses specific critical points (such as the inflection point, or points where scattered light reaches predetermined percentages of maximum value) to determine coagulation time. This extraction approach reduces the influence of noise and false detections while maintaining complete and accurate coagulation reaction information.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for accurate measurement of coagulation times in both normal and abnormal samples, reducing analysis time and improving efficiency in automated analysis.
Implementation Method 1
a mixed solution obtained by adding a reagent to a blood sample is illuminated with light, and the coagulation reaction of the blood sample is measured based on the resulting change in the amount of light. For example, when the amount of scattered light is measured, the scattered light intensity is sharply increased
Data Source
AI summary
Provided is a method for accurately measuring coagulation time of blood samples showing various coagulation reactions. The method for measuring blood coagulation time includes measuring coagulation reaction of a sample prepared by mixing a subject specimen and a coagulation time measurement reagent; calculating weighted average time of a calculation target area of a waveform related to coagulation velocity from the resulting measurement data; and determining the weighted average time as blood coagulation time.