Blood Coagulation Analysis Using Selective Waveform Smoothing
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Solution Overview
Problem
Existing methods for analyzing blood coagulation characteristics struggle to accurately evaluate abnormalities in coagulation factor activities, especially when the primary differential curve is not unimodal, leading to loss of waveform information and incomplete clinical representation.
Innovation Solution
A method that involves acquiring a waveform related to coagulation rate or acceleration from a blood specimen mixed with a reagent, extracting multiple parameters characterizing these waveforms, and determining the activity level or abnormality of coagulation factors VIII and IX based on these parameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If smoothing treatment is performed to make the primary differential curve unimodal, then the curve becomes suitable for parameter determination, but waveform information is lost and clinical representation becomes incomplete
Solution Approach 1:
The patent applies partial smoothing by selectively smoothing only specific portions of the primary differential curve that contain noise, while preserving the characteristic waveforms. This involves determining whether each region requires smoothing based on local characteristics, applying smoothing only where necessary, and controlling the smoothing intensity to maintain waveform features. This resolves the contradiction by achieving sufficient noise reduction for parameter determination without excessive smoothing that would destroy clinical information.
Solution Approach 2:
The patent implements local quality by applying different processing strategies to different regions of the curve. The method identifies specific regions (such as the ascending phase, peak region, and descending phase) and applies appropriate smoothing intensity or no smoothing at all based on the local waveform characteristics and clinical significance. This allows precise parameter determination in critical regions while preserving informative features in other regions.
2Loss of information
If no smoothing treatment is applied, then waveform information is preserved, but parameter determination becomes inaccurate due to non-unimodal curves
Solution Approach 1:
The patent applies partial smoothing by selectively smoothing only specific portions of the primary differential curve that contain noise, while preserving the characteristic waveforms. This involves determining whether each region requires smoothing based on local characteristics, applying smoothing only where necessary, and controlling the smoothing intensity to maintain waveform features. This resolves the contradiction by achieving sufficient noise reduction for parameter determination without excessive smoothing that would destroy clinical information.
Solution Approach 2:
The patent changes the parameter of smoothing intensity from a fixed high value to a variable low value that adapts to local curve characteristics. By adjusting the smoothing parameter dynamically based on the degree of non-unimodality and local noise levels, the method achieves adequate parameter determination accuracy while minimizing information loss. This parameter adaptation allows the system to maintain waveform fidelity while still enabling reliable parameter extraction.
3Productivity
If conventional parameter evaluation methods are used on non-unimodal curves, then analysis can be performed quickly, but the evaluation of blood coagulation characteristics becomes inaccurate
Solution Approach 1:
The patent applies partial smoothing by selectively smoothing only specific portions of the primary differential curve that contain noise, while preserving the characteristic waveforms. This involves determining whether each region requires smoothing based on local characteristics, applying smoothing only where necessary, and controlling the smoothing intensity to maintain waveform features. This resolves the contradiction by achieving sufficient noise reduction for parameter determination without excessive smoothing that would destroy clinical information.
Solution Approach 2:
The patent implements local quality by applying different processing strategies to different regions of the curve. The method identifies specific regions (such as the ascending phase, peak region, and descending phase) and applies appropriate smoothing intensity or no smoothing at all based on the local waveform characteristics and clinical significance. This allows precise parameter determination in critical regions while preserving informative features in other regions.
Data Source
AI summary
To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.