Centrifugal Blood Component Collection With Flow Rate Feedback
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Solution Overview
Problem
Existing separation processes struggle to efficiently isolate target components from multi-component fluids, such as blood, while maintaining high purity and minimizing the collection of other components, and often require prolonged processing times.
Innovation Solution
A separation system that includes a processor to adjust the flow rate of multi-component fluids based on component concentration, using a centrifugal field to separate and collect components in a controlled manner, maintaining the concentration of components below predetermined levels to ensure high purity and efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the separation process is performed quickly to reduce processing time, then productivity is improved, but the purity of the target component may be compromised
Solution Approach 1:
The system dynamically adjusts the flow rate of multi-component fluid through the separation vessel based on real-time concentration measurements. The processor receives first data indicating component concentration and determines an adjustment to change the amount of fluid introduced, allowing the separation process to adapt its speed while maintaining purity requirements
Solution Approach 2:
The system implements a feedback control mechanism where concentration data from the separation chamber is continuously monitored and fed back to the processor. This feedback loop enables real-time adjustments to the flow rate, ensuring that purity thresholds are maintained while optimizing processing speed
2Productivity
If the flow rate is increased to improve productivity, then processing time is reduced, but the concentration control of components becomes more difficult
Solution Approach 1:
The system changes the flow rate parameter dynamically based on concentration measurements. The processor adjusts the amount of multi-component fluid introduced into the separation vessel according to real-time concentration data, optimizing both collection rate and concentration control throughout the separation process
3Manufacturing precision
If the separation process is extended to improve purity, then manufacturing precision is improved, but productivity deteriorates
Solution Approach 1:
The system transitions from static, fixed-duration separation processes to dynamic processes that adjust flow rate in real-time. This allows the system to achieve high purity standards while minimizing processing time by optimizing the separation rate throughout the process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively separates and collects target components with minimal impurities, optimizing the process duration by dynamically adjusting fluid flow and centrifugal force based on real-time component data, thereby enhancing purity and reducing processing time.
Implementation Method 1
a separation vessel configured to receive the multi-component fluid and separate a composite fluid from the multi-component fluid
Data Source
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AI summary
Embodiments are described for separating/collecting components from a multi-component fluid such as whole blood. Some embodiments provide for controlling the amount of a component, such as platelets, introduced into a separation chamber to ensure that the density of fluid in the separation chamber does not exceed a particular value. This may provide for collecting purer components. Other embodiments may provide for determining a chamber flow rate based on a concentration of a component in the multi-component fluid, which may then be used to determine a centrifuge speed, to collect purer concentrated components.