Integrated Blood Collection Device for Closed Plasma Separation
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Solution Overview
Problem
Current blood sampling techniques are device-intensive, time-consuming, and costly, with multiple devices required for collection, preparation, and testing, leading to inconsistent results and increased exposure of blood samples during point-of-care testing.
Innovation Solution
A biological fluid collection device that separates plasma from cellular components within a closed system, allowing for fast mixing with a sample stabilizer and direct transfer to a point-of-care testing device without external machinery, reducing sample exposure and processing time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If multiple devices (needles, vacuum tubes, syringes) are used for blood collection and preparation, then blood sampling can be performed, but device complexity increases and processing time increases
Solution Approach 1:
The patent combines multiple separate devices (needle, vacuum tube, syringe, centrifuge, plasma separator) into a single integrated blood collection device. The housing contains all necessary components in one unit, allowing blood collection, separation, and plasma transfer to occur without requiring multiple separate devices, thus reducing device complexity while maintaining operational capability
Solution Approach 2:
The integrated device performs multiple functions within a single unit: it collects blood via needle, separates plasma from cellular components, stabilizes the sample, and transfers plasma to testing devices. This multi-functional design eliminates the need for separate specialized devices for each function, directly addressing the device complexity issue
2Ease of operation
If multiple devices are used for blood collection and preparation, then blood sampling can be performed, but time for processing increases
Solution Approach 1:
By merging all blood collection and separation functions into one integrated device, the patent eliminates the time required to transfer blood between multiple separate devices. The blood sample progresses through collection, separation, and plasma transfer within a single continuous operation, significantly reducing processing time
Solution Approach 2:
The device performs preliminary separation and stabilization actions automatically during the collection process. The plasma is separated and stabilized in the same device before transfer to the testing device, eliminating subsequent preparation steps and reducing overall processing time
3Ease of operation
If multiple devices are used for blood collection and preparation, then blood sampling can be performed, but cost increases
Solution Approach 1:
The patent consolidates multiple expensive separate devices into one integrated unit. While the integrated device has higher upfront cost, it eliminates the need to purchase and maintain multiple separate devices (needle set, vacuum tubes, syringes, centrifuge, plasma separator), potentially reducing overall system cost and complexity
4Ease of operation
If blood sample is transferred through multiple devices, then blood sampling can be performed, but exposure of blood sample increases
Solution Approach 1:
The patent employs a closed system with flexible membranes and sealed chambers that contain the blood sample throughout the collection and separation process. The blood remains enclosed within the housing and its components, preventing exposure to the external environment and reducing contamination risks while allowing the sampling process to proceed
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides a safer, more accurate, and reproducible process for blood sampling by minimizing exposure, eliminating waste, and enabling integrated collection and plasma transfer within a closed system, enhancing the reliability of point-of-care testing.
Implementation Method 1
a separation member adapted to separate the plasma portion from the cellular portion of the blood sample
Implementation Method 2
The sample stabilizer or preservative, can be an anticoagulant, or a substance designed to preserve a specific element within the blood
Data Source
AI summary
A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collection of the blood sample, the plasma portion is separated from the cellular portion. After separation, the biological fluid collection device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid collection device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid collection device is engageable with a biological fluid testing device for closed transfer of a portion of the plasma portion from the biological fluid collection device to the biological fluid testing device. The biological fluid testing device is adapted to receive the plasma portion to analyze the blood sample.