Blood Component Collection Prioritizing Platelets Over Plasma
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Solution Overview
Problem
Automated blood collection systems often prioritize plasma collection over platelet collection, leading to premature termination of the donation process and reduced platelet yields due to reaching hypovolemic limits.
Innovation Solution
Implementing a method that includes a pre-platelet plasma collection phase, followed by a platelet collection phase, and then a post-platelet plasma collection phase, with real-time adjustments to ensure maximum platelet collection while maintaining safe donation limits, allowing for continued collection beyond initial plasma completion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If automated blood collection systems continuously monitor and tune the collection process to maintain hypovolemic limits, then donor safety is ensured, but platelet collection is limited because plasma collection finishes first and triggers hypovolemic limits causing premature termination of the donation process
Solution Approach 1:
The collection process is segmented into distinct phases: an initial plasma collection phase followed by a platelet collection phase. This segmentation allows the system to collect plasma first, then switch to prioritizing platelet collection without being constrained by continuous plasma collection limits, thereby increasing overall platelet yield while maintaining donor safety through structured phase transitions.
Solution Approach 2:
The system dynamically adjusts collection priorities in real-time based on the phase of collection. During the initial phase, plasma collection is prioritized, but once a threshold is reached, the system dynamically switches to prioritize platelet collection. This dynamic adjustment allows the system to maximize platelet yield while continuously monitoring and maintaining hypovolemic limits for donor safety.
2Quantity of substance
If plasma collection is prioritized to meet minimum plasma volume requirements, then plasma donation goals are achieved, but the donation process terminates early due to reaching hypovolemic limits before maximum platelet collection
Solution Approach 1:
The system performs preliminary plasma collection in an initial phase to meet minimum plasma volume requirements before transitioning to the platelet collection phase. This preliminary action ensures plasma donation goals are achieved early, then allows the donation process to continue longer with platelet collection as the priority, preventing premature termination and maximizing overall component yield.
Solution Approach 2:
The system maintains continuous useful action by transitioning from plasma collection to platelet collection without interrupting the donation process. When plasma collection reaches its threshold, the system seamlessly continues with platelet collection, ensuring the donation process does not terminate early and maximizing the total useful output from the donor.
3Reliability
If the collection process is terminated when plasma collection reaches predicted volumes, then hypovolemic limits are maintained, but platelet collection is restricted because the system initiates rinseback instead of continuing platelet separation
Solution Approach 1:
The system dynamically changes collection priorities based on the phase and real-time conditions. During the platelet collection phase, even when plasma volume thresholds are reached, the system maintains platelet collection as the active process rather than initiating rinseback. This dynamic priority adjustment allows complete platelet collection while continuously monitoring hypovolemic limits to ensure donor safety.
Solution Approach 2:
The system changes operational parameters by switching from a plasma-collection-optimized mode to a platelet-collection-optimized mode. This parameter change allows the system to continue platelet separation at full efficiency even after plasma collection reaches predicted volumes, preventing premature termination and ensuring complete platelet recovery while maintaining hypovolemic limit adherence through continuous monitoring.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables prioritization of platelet collection over plasma, optimizing the collection of platelets while adhering to hypovolemic limits, thereby increasing the yield of platelets and ensuring safe donation volumes.
Implementation Method 1
separating a first amount of plasma from whole blood received from the subject
Data Source
AI summary
A method for collecting blood components includes separating a first amount of plasma from whole blood; separating a total amount of collectable platelets from the whole blood as available after the separation of the first amount of plasma; if a total collected amount is less than a maximum as adjusted by real-time data regarding collection following the separation of the total amount of platelets, separating a second amount of plasma from the whole blood as available after the separation of the total amount of platelets and then separating a total amount of red blood cells from the whole blood as available after the separation of the second amount of plasma; and if the total collected amount is at the maximum as adjusted by real-time data regarding collection, separating the total amount of red blood cells from the whole blood as available after the separation of the total amount of platelets.