Blood Component Measurement Device Error Suppression
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Solution Overview
Problem
Existing blood component measurement devices face errors in determining analyte concentration due to insufficient suppression of measurement errors in the output signals from the sensor system, which affects the accuracy and precision of blood component analysis.
Innovation Solution
A blood component measurement device and method that utilize a biosensor system with multiple current value measurements and conversion techniques, including storage of recorded data for comparison to calculate the blood component amount, employing oxidation-reduction reactions and voltage applications to electrode pairs, to enhance accuracy and reduce measurement errors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple duty cycles of sequential excitation pulses are input into the sample to improve measurement accuracy, then the accuracy and precision of analyte concentration determination are improved, but the measurement time and complexity of the measurement process increase
Solution Approach 1:
The patent applies preliminary action by performing multiple excitation pulses and measurements before final result determination. The system accumulates data from multiple duty cycles of sequential excitation pulses, analyzing output signals within 300ms after each pulse to build a comprehensive dataset that improves accuracy before concluding the measurement
Solution Approach 2:
The patent implements periodic action through sequential excitation pulses applied at regular intervals. Multiple duty cycles of excitation pulses are input into the sample in sequence, with each pulse followed by measurement of output signals, creating a periodic measurement pattern that enhances precision through repeated sampling
2Measurement precision
If multiple excitation pulses are applied to measure analyte concentration, then measurement accuracy is improved, but the complexity of the measurement system and signal processing increases
Solution Approach 1:
The patent applies segmentation by dividing the measurement process into distinct temporal phases corresponding to different duty cycles of excitation pulses. Each pulse generates separate output signals that are processed independently within their respective time windows (within 300ms after each pulse), allowing complex measurements to be broken into manageable segments that can be analyzed separately and combined for final results
3Measurement precision
If Hct value measurement is used to correct component amount in blood, then measurement accuracy is improved, but additional measurement steps and system complexity are required
Solution Approach 1:
The patent merges the measurement of multiple blood components (glucose and hematocrit) into a single integrated sensor system. The sensor simultaneously performs oxidoreduction reactions for glucose detection and impedance measurements for hematocrit determination, combining multiple measurement functions into one device that shares common structural elements and processing infrastructure
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed solution effectively suppresses errors in measuring blood components by using multiple current value measurements and data conversion methods, improving the accuracy and precision of blood component analysis.
Implementation Method 1
the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode
Implementation Method 2
a redox current caused when a voltage is applied by the first electrode
Implementation Method 3
applying a voltage to cause a current to flow, and detecting a value of the current
Data Source
Figure 1~3
Figure 4
Figure 5~6
AI summary
Provided are a blood component measurement device and the like capable of further suppressing the errors in measuring blood components. A first current value that is generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 composing a biosensor 1 is measured, a second current value that is generated when a second voltage is applied to a second electrode pair 23, 24 composing the biosensor 1 is measured, and then the first current and the second current are converted to give a blood component amount. Within a predetermined period after the introduction of blood into the biosensor 1, the first current is measured multiple times and the second current is measured once. A CPU 72 converts a plurality of first current values and the second current value to obtain a plurality of blood component amounts and calculates the blood component amount for the blood introduced into the biosensor 1 from said plurality of blood component amounts.