Blood Container Anti-Fouling Zwitterionic Polymer Coating
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Solution Overview
Problem
Low-yield platelet-rich plasma (PRP) production due to blood adherence in centrifugal tubes made of PET or PP materials, which can cause inflammatory reactions from silicone oil binding with proteins, necessitating an improvement in blood container design to prevent blood adherence and inflammatory reactions.
Innovation Solution
A blood container with an anti-fouling layer containing a zwitterionic polymer, such as 2-methacryloyloxyethyl phosphorylcholine, sulfobetaine methacrylate, or carboxybetaine methacrylate, applied to the inner surface to create a hydrated layer with a covering rate of 50% to 100%, preventing blood and protein adherence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If silicone oil is coated on the tube wall to improve smoothness and reduce blood adherence, then the probability of blood remaining on the tube wall is reduced, but silicone oil binds with proteins to form microspheres that cause inflammatory reactions
Solution Approach 1:
The patent changes the chemical composition parameters of the coating material from silicone oil to zwitterionic polymer, which fundamentally alters the interaction mechanism with blood proteins. The zwitterionic polymer maintains the smoothness benefit while eliminating the harmful protein-binding effect that causes inflammation
Solution Approach 2:
The patent uses a composite coating structure comprising a zwitterionic polymer layer that combines hydrophilic and hydrophobic moieties, creating a surface that repels blood proteins while maintaining smooth blood flow. This composite material approach resolves the contradiction by integrating multiple functional properties in one coating system
2Ease of manufacture
If plastic centrifugal tubes with poor hydrophobicity are used, then manufacturing cost is reduced, but blood easily clings to the tube wall resulting in lower PRP yield
Solution Approach 1:
The patent applies a preliminary coating treatment to the plastic tube surface before blood collection. This pre-treatment with zwitterionic polymer creates an antifouling surface that prevents blood adherence, thereby maintaining high PRP yield while using cost-effective plastic materials
Solution Approach 2:
The zwitterionic polymer coating acts as an intermediary layer between the plastic tube wall and blood components. This intermediate layer prevents direct interaction between blood proteins and the plastic surface, eliminating blood clinging while preserving the low-cost plastic substrate
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The anti-fouling layer effectively prevents blood and protein adherence, enhancing PRP yield and reducing the risk of inflammatory reactions, while the manufacturing method can be applied to various blood containers within minutes, providing high hydration capacity and antifouling properties.
Implementation Method 1
the anti-fouling layer to be hydrated covers the inner wall surface and contains a hydration polymer
Implementation Method 2
one or more surfaces with high hydration capacity and good antifouling properties
Data Source
AI summary
A blood container and a method for manufacturing the same are provided. The blood container includes a container body and an anti-fouling layer to be hydrated. The container body has an inner wall surface, and the anti-fouling layer to be hydrated covers the inner wall surface and contains a hydration polymer. A covering rate of the hydration polymer on the inner wall surface is from 50% to 100%.