Differentiating Blood and Control Solutions via Spectral Labeling
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Solution Overview
Problem
Optical instruments used for measuring analytes in biological fluids, such as glucose in blood samples, face challenges in distinguishing between measurements from control solutions and actual blood samples, leading to potential errors in recorded data history.
Innovation Solution
Incorporating a labeling substance, such as a water-soluble dye like indocyanine green, into control solutions that absorbs light at a specific wavelength, allowing optical instruments to differentiate between control solutions and blood samples by recognizing the unique spectral response.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If control solutions are formulated to respond similarly to blood samples, then measurement accuracy is improved, but the ability to distinguish control solutions from blood samples deteriorates
Solution Approach 1:
The patent applies color changes by incorporating a dye into the control solution that absorbs light at a specific wavelength (600-800 nm). This dye causes the control solution to have a distinct spectral response compared to blood samples, while still allowing accurate glucose measurement through the enzyme reaction. The color-absorbing property enables the optical instrument to differentiate control solutions from blood samples based on their unique light absorption characteristics.
Solution Approach 2:
The patent uses a dye as an intermediary substance that mediates between the control solution and the optical instrument's detection system. The dye acts as a marker that the optical instrument can detect, providing information about the sample type without interfering with the glucose measurement process. This intermediary allows the system to recognize control solutions and exclude them from patient glucose history records.
2Ease of operation
If control solutions contain colored additives to mimic blood appearance, then ease of operation is improved, but measurement precision deteriorates due to light interference
Solution Approach 1:
The patent resolves this contradiction by moving the differentiation to another dimension - the spectral dimension. Instead of relying on visible color appearance to mimic blood, the dye absorbs light at a specific wavelength range (600-800 nm) that is distinct from the glucose detection wavelength. This allows the control solution to have a unique spectral fingerprint for identification while maintaining accurate glucose measurement through the enzyme-catalyzed color reaction.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and reliable measurement of glucose in blood samples by preventing the inclusion of control solution data in the recorded history, ensuring accurate patient treatment records and reducing manual separation errors.
Implementation Method 1
Incorporating a labeling substance, such as a water-soluble dye like indocyanine green, into control solutions that absorbs light at a specific wavelength
Data Source
AI summary
Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.