Automated Blood Cell Counting for Immediate Immune Subgroup Analysis
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Solution Overview
Problem
Current clinical methods for examining immunodynamics, particularly in lymphocyte subgroups, are complex, expensive, and provide only static information, making it difficult to obtain immediate and detailed insights into immune cell dynamics such as Th1 cells, Th2 cells, Th17 cells, and regulatory T cells, which are crucial for early disease detection and treatment.
Innovation Solution
A multi-parameter automatic blood cell counting device that integrates a blood cell count detector, surface antigen CD number detector, storage, and display to quickly calculate and display the total number of immune cells like helper T cells, killer T cells, B cells, NK cells, and NKT cells, forming immunodynamic patterns and models based on CD antigen analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If conventional examination methods are used to obtain detailed immune cell information, then comprehensive immune status data can be acquired, but the examination process becomes complex and expensive
Solution Approach 1:
The patent combines multiple examination functions into a single automated blood cell counting device that can simultaneously perform basic blood cell counts and detailed immune cell subgroup analysis, eliminating the need for separate specialized examinations and reducing overall examination complexity
Solution Approach 2:
The device is designed with multi-functionality to handle both routine blood cell counting and specialized immune cell analysis (including Th1, Th2, Th17, and regulatory T cells) using a single system, making the device applicable to a wide range of clinical scenarios without requiring multiple specialized devices
2Loss of information
If specialized examination methods are used for detailed immune cell analysis, then comprehensive immune dynamics information can be obtained, but the cost increases significantly
Solution Approach 1:
The patent employs disposable test strips that are inexpensive to manufacture and use, replacing the need for expensive reusable specialized equipment and reagents, thereby significantly reducing the cost of detailed immune cell analysis while maintaining comprehensive data collection capabilities
3Loss of information
If conventional examination methods are used, then static immune cell data can be obtained, but immediate immunodynamics information cannot be acquired
Solution Approach 1:
The automated device enables continuous and immediate analysis of immune cell dynamics without interruption or delay, providing real-time data on immune cell subgroups and their changes, which allows for immediate clinical decision-making rather than waiting for batch processing of specialized examinations
4Loss of information
If multiple immune cell subgroups are examined simultaneously, then comprehensive immune status can be assessed, but the examination becomes highly unreasonable in clinical practice
Solution Approach 1:
The device performs automated analysis of multiple immune cell subgroups without requiring manual intervention or complex sample preparation by medical staff, with the system automatically identifying, counting, and analyzing different cell types (Th1, Th2, Th17, regulatory T cells, etc.) based on their surface markers, making the complex examination as easy to operate as a routine blood count
Data Source
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AI summary
[Problem] A multi-parameter automatic blood cell counting device that can immediately acquire information of immunodynamics and accurately comprehend immune status is provided. [Solution] The multi-parameter automatic blood cell counting device includes a basic information generator; an immune cell subgroup detector; an immunodynamic change analyzer; a storage; and a display, wherein the basic information generator is configured to acquire examination information of a blood count of blood components and a white blood cell image, and analysis information of a CD classification of monoclonal antibodies that bind to lymphocyte surface antigens, the immune cell subgroup detector is configured to detect information of immune cell subgroups required for analyzing an immune status of a subject based on the examination information of the blood count of the blood components and the white blood cell image, and the analysis information of the CD classification of the monoclonal antibodies that bind to lymphocyte surface antigens, and the immunodynamic change analyzer is configured to identify information related to a change in immunodynamics of the subject based on the information examined in the basic information generator and the immune cell subgroup detector, and data stored in the storage, and to create and display an image of the identified information on the display.