Multi-Component Blood Analysis for Early Disease Detection
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Solution Overview
Problem
Current diagnostic methods focus on single components of blood, leading to loss of potentially important information and are not effective for early detection or personalized diagnosis of diseases, especially in individuals without known conditions.
Innovation Solution
A method using combinations of cell-free bodily fluids, phagocytic cells, circulating vesicles, and circulating diseased cells to determine disease-specific markers, enabling diagnosis, prognosis, and monitoring by comparing profiles from these samples with control profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If single component blood testing is used, then the testing process is simple, but important diagnostic information is lost
Solution Approach 1:
The patent combines multiple blood components (plasma, leukocytes, platelets) that are typically tested separately into a single integrated diagnostic system. This merging allows simultaneous analysis of different cell types and their markers, preserving diagnostic information that would be lost in separate testing while maintaining operational simplicity through automated processing.
Solution Approach 2:
The diagnostic system is designed to perform multiple functions by analyzing various blood components simultaneously - detecting cancer markers in plasma, identifying circulating tumor cells in leukocytes, and examining platelet characteristics. This multi-functional approach eliminates the need for separate targeted tests while comprehensive diagnostic information.
2Ease of manufacture
If population-derived averages are used for diagnosis, then the diagnostic process is standardized, but personalized diagnosis is compromised
Solution Approach 1:
The patent employs local quality by analyzing specific markers and characteristics tailored to each patient's unique blood sample composition rather than applying uniform population averages. The system identifies and measures disease-specific markers in each component (e.g., cancer-associated antigens in plasma, specific surface markers on circulating tumor cells) to provide personalized diagnostic information while maintaining standardized analytical procedures.
Data Source
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AI summary
This invention provides methods of using a sample with multiple analytical components in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of identifying markers of diseases or conditions.