Blood Filtering Apparatus with 2-3 Micron Cell Filter

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Solution Overview

Problem

Current methods for blood component separation, particularly in autologous blood transfusion, are inefficient and costly, leading to damage of red blood cells and platelets, and require complex equipment and skilled personnel, with limited shelf life for platelet concentrates and complications from combining components from different donors.

Innovation Solution

A blood filtering apparatus with a cell filter having a pore size of 2.0-3.0 microns effectively retains red blood cells and platelets while allowing smaller impurities to pass, enabling the production of red blood cell and platelet-rich compositions with minimal equipment and low pressure differences, reducing shear stress and contamination risks.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If centrifugal separation is used to separate blood components, then separation efficiency is improved, but red blood cells and platelets are damaged and lost

Engineering Contradiction:
Improveseparation efficiencyVSAvoidintegrity of red blood cells and platelets
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent replaces the centrifugal mechanical separation system with a filtration-based separation system. The filtration system uses a filter with specific pore sizes (2-3 μm for RBCs, 0.5-2 μm for platelets) to separate blood components without the mechanical forces that cause cell damage in centrifugal methods. This substitution maintains separation efficiency while preserving cell integrity.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If centrifugal equipment and skilled personnel are used for blood separation, then separation capability is improved, but device complexity and operational difficulty increase

Engineering Contradiction:
Improveseparation capabilityVSAvoidequipment complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent extracts the core separation function from the complex centrifugal equipment and implements it through a simple filtration system. The filter membrane with controlled pore sizes performs the separation function that previously required entire centrifugal machines, skilled operators, and complex control systems. This reduces device complexity while maintaining separation capability.

Inventive Principle:
Principle #2Taking out (Extraction)

3Quantity of substance

If platelet concentrates are prepared using conventional methods, then platelet recovery is achieved, but shelf life is limited

Engineering Contradiction:
Improveplatelet recoveryVSAvoidshelf life
Core Design Contradiction:
Quantity of substanceVSDuration of action of stationary object

Solution Approach 1:

The patent uses porous filter materials with specific pore size ranges (0.5-2 μm for platelet filtration) that allow gentle separation of platelets from blood without the mechanical stress of centrifugation. This gentle filtration method preserves platelet viability and function, extending the shelf life of platelet concentrates while maintaining effective platelet recovery.

Inventive Principle:
Principle #31Porous materials

4Productivity

If blood components from different donors are combined, then blood product availability is improved, but risk of complications increases

Engineering Contradiction:
Improveblood product availabilityVSAvoidrisk of complications
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent enables autologous blood separation where each patient's blood is filtered and processed individually using the portable filtration device. The blood components are separated and can be reinfused into the same patient, eliminating the need to combine components from different donors. This self-service approach maintains blood product availability for autologous transfusion while eliminating immunological complications associated with allogeneic transfusions.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus provides a reliable, cost-effective method for producing platelet-rich and red blood cell-rich compositions with reduced risks of complications, enabling continuous manufacturing and extended shelf life, while maintaining the integrity of blood components for autotransfusion and homotransfusion.

Implementation Method 1

a cell filter configured for filtering a portion of the blood and retaining as a retentate a fraction of the blood containing red blood cells and platelets and passing as a filtrate a fraction of the blood containing platelets and being depleted of red blood cells. The cell filter has a pore size in a range of 2.0-3.0 micron.

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Data Source

PatentUS20230173147A1Blood separation system and blood products
Publication Date: 2023.06.08 HEMOCLEAR BV
  • US20230173147A1 patent drawing
  • US20230173147A1 patent drawing
  • US20230173147A1 patent drawing

AI summary

A blood filtering apparatus for recovering blood components from blood comprises an inlet for the blood; a cell filter configured for filtering a portion of the blood and retaining as a retentate a fraction of the blood containing red blood cells and platelets and passing as a filtrate a fraction of the blood, in particular mainly as plasma, containing platelets and being depleted of red blood cells. The cell filter has a pore size in a range of 2,0-3.0 micron. Further, a method and a blood product are provided.