Whole Blood Glucose Correction Using Hematocrit and Sensor Response
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Solution Overview
Problem
Existing methods for measuring glucose concentration in blood plasma using whole blood samples face discrepancies due to hematocrit values, especially at high concentrations, leading to inaccuracies.
Innovation Solution
A method and apparatus that utilize electrochemical sensors to measure whole blood component concentrations, calculate correction values based on hematocrit values and sensor responses, and apply formulas to determine plasma component concentrations, including glucose, by correcting for discrepancies using hematocrit and sensor index factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If glucose concentration is measured using whole blood sample with conventional conversion formula, then measurement process is simplified, but measurement precision deteriorates due to hematocrit value discrepancies
Solution Approach 1:
The patent introduces a correction formula that incorporates hematocrit value as an additional parameter to adjust the glucose concentration measurement. By changing the measurement parameters from a simple conversion to a multi-parameter correction system, the patent resolves the contradiction by maintaining operational simplicity while improving measurement precision through hematocrit-based adjustment.
Solution Approach 2:
The patent implements a feedback mechanism where the measured glucose concentration and hematocrit value are used to calculate a correction value, which is then applied to obtain the final accurate plasma glucose concentration. This feedback loop ensures that measurements are continuously adjusted based on actual hematocrit conditions, resolving the precision issue while maintaining ease of operation.
2Measurement precision
If correction formula incorporating hematocrit value is applied, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent develops a universal correction formula that can be applied across different hematocrit values and glucose concentration levels using a single standardized equation. This multi-functional approach allows the system to handle various measurement conditions without requiring multiple specialized devices or complex calculation systems, thus improving precision while limiting complexity increase.
3Device complexity
If conventional conversion formula is used, then device complexity is minimized, but reliability deteriorates at high glucose concentrations and hematocrit values
Solution Approach 1:
The patent performs preliminary measurement of hematocrit value before applying the correction formula to glucose concentration. By preparing the hematocrit data in advance and incorporating it into the correction calculation, the system ensures reliable measurements at high glucose concentrations and hematocrit values without significantly increasing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate measurement of plasma component concentrations, such as glucose, from whole blood samples, regardless of hematocrit values, improving measurement precision.
Implementation Method 1
measuring a whole blood component concentration using a whole blood sample, using an electrochemical sensor method
Data Source
AI summary
Provided is a method for reducing the discrepancy between a measured value of component concentration in whole blood and a measured value of component concentration in plasma. A method for measuring a plasma component concentration using a whole blood sample includes: measuring a whole blood component concentration using a whole blood sample, using an electrochemical sensor method; computing a correction value using a whole blood component concentration measured value obtained through the measurement, a hematocrit value of the whole blood sample, and a response index of a sensor used for the measurement of the whole blood component concentration; and computing a plasma component concentration using the correction value and the whole blood component concentration measured value.