Blood Glucose Measurement With Core-Temperature Compensation
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Solution Overview
Problem
Existing continuous glucose monitoring (CGM) devices face inaccuracies in blood glucose measurements due to discrepancies between tissue fluid glucose concentration and actual blood glucose concentration, exacerbated by temperature variations.
Innovation Solution
Implementing a method that determines core body temperature and sensor temperature using skin temperature and physiological parameters to accurately calibrate glucose readings, thereby improving the accuracy of blood glucose concentration calculations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If a biosensor is implanted subcutaneously to measure tissue fluid glucose concentration, then continuous glucose monitoring is achieved, but measurement accuracy deteriorates due to temperature variations and discrepancies between tissue fluid glucose and blood glucose
Solution Approach 1:
The patent introduces temperature as an intermediary parameter to bridge the gap between tissue fluid glucose measurement and actual blood glucose concentration. By measuring temperature at multiple locations (skin surface and core body temperature) and using it as a mediator to compensate for the discrepancies, the system achieves more accurate blood glucose calculations while maintaining continuous monitoring capability
Solution Approach 2:
The patent changes the measurement parameters by incorporating temperature compensation into the glucose measurement system. Instead of relying solely on glucose concentration measurements, the system measures temperature parameters (skin temperature, core body temperature) and uses these parameter changes to correct and compensate for measurement errors, thereby improving overall measurement accuracy
2Device complexity
If temperature compensation is implemented using skin temperature only, then the measurement system remains simple, but measurement accuracy deteriorates because skin temperature does not reflect core body temperature
Solution Approach 1:
The patent segments the temperature measurement into multiple independent components: skin surface temperature measurement and core body temperature measurement. By dividing the temperature monitoring into separate measurement points and processing each independently, the system achieves more accurate sensor temperature determination without creating a single complex measurement system
Solution Approach 2:
The patent uses core body temperature as an intermediary to improve sensor temperature accuracy. Since the glucose sensor operates in subcutaneous tissue, its temperature is better represented by core body temperature rather than skin surface temperature. By introducing core body temperature as a mediator parameter, the system achieves more accurate compensation
Data Source
Figure 1A~1B
Figure 1C~1D
Figure 2A
AI summary
A blood glucose measurement method, an electronic device (100), and a system are provided. The blood glucose measurement method includes: first determining a core temperature of a human body, determining a sensor temperature based on the core temperature, a skin temperature, and a physiological parameter, and performing temperature compensation on blood glucose measurement, to obtain a blood glucose concentration with higher accuracy.