Multi-Blood Group Test Card With Encoded Rapid Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing blood grouping methods are time-consuming, require specialized equipment, and are not suitable for resource-scarce areas, leading to inefficiencies and increased error rates, especially in emergency situations.
Innovation Solution
An automatic test card integrating barcode and two-dimensional code technologies for rapid, portable, and automated detection of multiple blood groups, utilizing a multi-layer structure with pre-coated antibodies and antigens, and compatible with general-purpose devices for result interpretation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional test tube method or cassette microcolumn gel method is used for blood grouping, then accurate results are obtained, but the testing process becomes time-consuming and increases clinical workload
Solution Approach 1:
The test card is divided into multiple independent test zones, each containing specific antibodies (anti-D, anti-C, anti-E, anti-c, anti-e) pre-coated on the membrane. This segmentation allows simultaneous detection of multiple blood group antigens in a single operation, reducing testing time while maintaining accuracy through parallel processing of different blood group systems
Solution Approach 2:
The antibodies are pre-coated and immobilized on the test card membrane during manufacturing, preparing the reagents in advance. This preliminary action eliminates the need for complex reagent preparation during clinical testing, allowing direct application of blood samples and significantly reducing the testing process time while ensuring reagent quality and consistency
2Reliability
If dedicated laboratory instruments and specialized reagents are used for blood grouping, then reliable detection is achieved, but the cost of instruments and reagents becomes high
Solution Approach 1:
The test card is designed as a self-contained diagnostic system where the membrane itself serves as both the support and the reagent carrier. The pre-coated antibodies are immobilized directly on the membrane, eliminating the need for separate reagent bottles, storage systems, and complex instrument equipment. Users simply apply blood samples and interpret results visually or with basic imaging devices, making the system self-sufficient and suitable for resource-limited settings while maintaining reliable detection
Solution Approach 2:
The test card is designed as a disposable single-use device with integrated reagents. Each card contains pre-coated antibodies that are stable at room temperature, eliminating the need for expensive refrigeration equipment and complex instrument systems. After one use, the card is discarded, ensuring no cross-contamination and eliminating the need for complex cleaning and maintenance procedures, thereby reducing overall system complexity and cost
3Stability of the object's composition
If commonly-used blood grouping reagents are stored at 4°C, then reagent stability is maintained, but long-term storage at room temperature becomes difficult
Solution Approach 1:
The antibodies are chemically modified through immobilization on the membrane surface, changing their physical and chemical parameters. This immobilization process creates stable antigen-antibody complexes that are resistant to temperature fluctuations, allowing the reagents to maintain stability at room temperature without requiring refrigeration. The membrane structure provides a stable environment that preserves antibody activity while enabling convenient storage in various clinical settings
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, accurate, and automated blood grouping without specialized equipment, reducing manual errors and improving detection efficiency, particularly in resource-scarce areas.
Implementation Method 1
the antibody pad is pre-coated with blood group antibodies... the antigen pad is pre-coated with blood group antigens... RBC surface antigens in the blood and specific antibodies in the plasma of a subject are detected. If there is a corresponding antigen on the surface of the RBC, then the antigen may agglutinate with a corresponding antibody reagent.
Implementation Method 2
the reaction layer is provided with a whole blood pad or a filter pad for filtering RBCs from whole blood
Implementation Method 3
blood grouping is achieved by judging the agglutination of the RBCs... the antigen may agglutinate with a corresponding antibody reagent
Data Source
AI summary
The present disclosure provides an automatic test card for a multi-blood group system and a test method. The test card of a multi-blood group system includes four parts from top to bottom: a sample loading layer, a reaction layer, a color developing layer, and an identification layer. The automatic test card for a multi-blood group system and the test method combines blood group detection with encoding, and can rapidly and automatically identify and test multiple blood groups, reduce manual judgment errors, and improve detection efficiency. The method does not require special equipment and achieves rapid, accurate, automated, and portable detection of the blood groups.