Blood Treatment Infusion Control via Dynamic Flow Adjustment
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Solution Overview
Problem
Existing blood treatment technologies for hemofiltration and hemodiafiltration lack dynamic control over pre and post-infusion flows, limiting solute clearance and being constrained by fixed infusion fluid amounts and sensor limitations.
Innovation Solution
A blood treatment equipment and method that dynamically adjusts pre and post-infusion flows using conventional sensors and controls to optimize solute clearance, employing a distribution device to split infusion fluid between pre and post-infusion lines based on real-time efficiency parameters, allowing for flexible infusion fluid management without pre-fixed total amounts.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If pre and post infusion flows are controlled according to pre-fixed set values, then device complexity is reduced, but solute clearance efficiency deteriorates
Solution Approach 1:
The patent implements dynamic control of pre and post infusion flows by continuously adjusting flow rates based on real-time sensor measurements of hematocrit and transmembrane pressure, replacing fixed set values with adaptive control algorithms that optimize solute clearance efficiency throughout the treatment process
Solution Approach 2:
The control system incorporates feedback loops that monitor hematocrit and transmembrane pressure parameters and use this information to automatically adjust infusion flow rates, creating a closed-loop control system that maintains optimal treatment conditions without requiring complex manual intervention
2Ease of operation
If total infusion fluid amount is pre-fixed, then fluid management is simplified, but treatment adaptability deteriorates
Solution Approach 1:
The system allows the total infusion fluid amount to dynamically adjust during treatment based on real-time monitoring of treatment efficacy and patient response, enabling the treatment protocol to adapt to changing conditions while maintaining straightforward fluid management through automated control
Solution Approach 2:
The patent enables modification of infusion flow rate parameters during treatment based on measured hematocrit and transmembrane pressure values, allowing the system to adapt total fluid delivery to actual treatment needs while keeping the interface simple for operators
3Device complexity
If conventional sensors and controls are used, then device complexity is reduced, but measurement precision and control accuracy deteriorate
Solution Approach 1:
The patent implements sophisticated feedback algorithms that process signals from conventional sensors to dynamically optimize pre and post infusion flows, using control theory techniques to extract maximum precision from standard sensor capabilities and compensate for their limitations through computational methods
Solution Approach 2:
The system optimizes measurement effectiveness by dynamically adjusting operating parameters such as flow rates and treatment conditions to maximize the information content from conventional sensor measurements, thereby achieving high precision control without requiring advanced sensors
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances solute clearance by dynamically optimizing infusion flows, improving the efficiency of blood treatment processes while utilizing conventional sensors and controls, ensuring efficient fluid management and treatment efficacy.
Implementation Method 1
a relevant volume of water (higher than in case of pure ultrafiltration) is removed from blood by creating a pressure difference between the first and the second chamber of the hemofilter
Implementation Method 2
blood purification is achieved by convective transfer of molecules. The molecules are removed from the blood by the water migrating in to the second chamber of the hemofilter
Implementation Method 3
In case of hemodiafiltration, a dialysis fluid is also sent into the second chamber of the hemofilter, thereby combining the convective purification with the diffusive purification of a dialysis treatment
Data Source
AI summary
A method and blood treatment equipment for controlling infusion are described. The equipment comprising: an extracorporeal blood circuit, a pre-infusion line connected to the blood circuit upstream a blood treatment unit, a post-infusion line connected to the blood circuit downstream the blood treatment unit, a waste line connected to an outlet of the treatment unit. A sensor operates on the waste line for sensing at least one fluid parameter and is connected to a control unit which commands a fluid flow through said pre-infusion line and through said post-infusion line. The control unit also determines from values of said fluid parameter at least a corresponding value of an efficiency parameter relating to blood depuration efficiency of the blood treatment unit, and controls the flow rate of at least one of the fluid flows through said infusion lines as a function of the value of the efficiency parameter. A software program for execution by the control unit is also claimed.