Autologous Blood Nosode Activation for Stronger HSA Binding
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Solution Overview
Problem
Existing methods for preparing autologous blood nosodes do not effectively combine the advantages of binding active substances to human serum albumin (HSA) in a gentle and efficient manner, limiting their therapeutic efficacy.
Innovation Solution
A method involving magnetic pulses and LED-activated light is used to bind active substances to autologous blood nosodes, enhancing the binding capacity of HSA by applying magnetic pulses within specific frequencies and field strengths, followed by mechanical shaking and color-changing LED irradiation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional methods for preparing autologous blood nosodes are used, then the preparation process is simple, but the binding capacity of HSA to active substances is insufficient
Solution Approach 1:
The patent applies preliminary action by activating the autologous blood nosode with magnetic pulses before adding active substances. This activation step prepares the HSA in advance to have enhanced binding capacity, ensuring that when active substances are subsequently added, they can be effectively bound and transported. The magnetic activation is performed as a pre-treatment step that modifies the HSA properties before the main binding process.
2Reliability
If magnetic pulses and LED irradiation are applied to activate the nosode, then the binding capacity of HSA increases, but the device complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the activation process into distinct functional modules: a magnetic pulse generation unit and an LED irradiation unit. These modules can operate independently or in combination, allowing the system to be configured based on specific treatment requirements. The segmentation enables easier maintenance, operation, and adaptation of the device while achieving the desired HSA activation effects.
3Strength
If active substances are bound to HSA through covalent bonding, then the binding is strong, but the method is harsh and may cause side effects
Solution Approach 1:
The patent replaces harsh chemical covalent bonding methods with a gentler physical approach using magnetic pulses and LED irradiation. This substitution activates the HSA to enhance its natural binding capacity without requiring aggressive chemical reactions. The physical activation methods preserve the integrity of the active substances while achieving effective binding, thereby reducing potential side effects associated with harsh chemical treatments.
4Productivity
If high-pressure homogenization is used to form nanoparticle suspension, then the drug delivery is improved, but the process complexity and energy consumption increase
Solution Approach 1:
The patent replaces high-pressure mechanical homogenization with a gentler activation process using magnetic pulses and LED irradiation. This substitution achieves effective drug binding to HSA without requiring extreme pressure and energy input. The magnetic and optical activation methods provide sufficient energy for HSA activation while consuming significantly less energy than high-pressure homogenization, thereby improving process efficiency and reducing energy costs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly increases the transport and efficacy of active substances to the desired site of action, ensuring efficient delivery and therapeutic outcomes.
Implementation Method 1
Activating the initial mixture by applying magnetic pulses with magnetic field period frequencies within a range of approximately 0.01 to approximately 20,000 Hz and field strengths of a maximum of 50 μT to the initial mixture
Implementation Method 2
irradiation of visible, LED-generated light of changing color into the shaken second mixture
Data Source
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AI summary
A method for binding an active substance or an active agent to an activated autologous blood nosode comprises a) dissolving blood of a patient in an aqueous or aqueous/ethanol medium or rubbing the blood of a patient with a carrier material approved for globules according to Germany's Homeopathic Pharmacopeia (HAB) to obtain a first mixture; b) activating the first mixture by reaction with magnetic pulses having frequencies of the magnet field periods within a range of approximately 0.01 to approximately 20,0000 Hz and maximum field strengths of 50 μΤ onto the first mixture; c) adding one, or one or more active substances and/or active agents to the activated first mixture to obtain a second mixture; d) succussion of the second mixture by mechanical effects, wherein the steps c) and d) are conducted under the continuous effects of the magnet pulses and wherein steps c) and d) can be repeated once or several times; and e) activating the succussed second mixture by the further continuous effect of the magnet pulses and by irradiation with visible light of changing colors produced by LEDs into the second succussed mixture, whereby an increase of the binding capacity of the human serum albumin (HSA) in the blood to the active substance(s) and/or to at least some of the active agent or active agents is effected. A device for carrying out the method is also described.