Blood Product PIC Dosing for Accurate Pathogen Inactivation
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Solution Overview
Problem
Existing systems lack efficient and accurate methods for dosing pathogen inactivation compounds into blood components, such as plasma, platelets, and red blood cells, which is crucial for minimizing the risk of transfusion-transmitted infections.
Innovation Solution
A method and system utilizing a device with fluid control components to determine and transfer the precise amount of pathogen inactivation compounds based on input parameters, such as weight and volume, using scalable and reusable fluid paths, pumps, and detectors for accurate dosing and mixing with blood compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If manual dosing methods are used for pathogen inactivation compounds, then device complexity is reduced, but dosing precision and accuracy deteriorate
Solution Approach 1:
The system automatically determines the amount of PIC needed based on input parameters (weight, volume) and performs the dosing operation without manual intervention. The device self-regulates the dosing process using integrated sensors and control algorithms, eliminating the need for complex manual dosing equipment while maintaining high precision.
Solution Approach 2:
The patent replaces manual mechanical dosing operations with an automated system that uses sensors, processors, and control algorithms to determine and deliver the precise amount of PIC. This substitution of mechanical/manual operations with automated control achieves high dosing precision without requiring complex mechanical dosing devices.
2Productivity
If rapid dosing is implemented to increase throughput, then productivity improves, but dosing accuracy may deteriorate
Solution Approach 1:
The system performs preliminary calculations to determine the exact amount of PIC needed based on input parameters before the actual dosing operation. This pre-determination step allows the rapid dosing process to proceed with high accuracy, as the target amount is already calculated and stored for precise delivery during the fast dosing phase.
Solution Approach 2:
The system uses detectors and sensors to monitor the dosing process in real-time and provides feedback to the control system. This feedback mechanism ensures that even during rapid dosing operations, the actual amount delivered matches the calculated target amount, maintaining high accuracy while achieving fast throughput.
3Reliability
If frangible pathogen inactivation compounds are used for RBC inactivation, then pathogen inactivation effectiveness improves, but compound stability deteriorates
Solution Approach 1:
The system performs preliminary calculations to determine the exact amount of frangible compound needed based on the specific blood composition parameters. By pre-determining the precise dosage, the system minimizes the time the unstable compound is exposed to environmental conditions, reducing degradation while ensuring sufficient quantity for effective pathogen inactivation.
Solution Approach 2:
The patent replaces manual handling and timing operations with automated systems that rapidly mix and process the frangible compound. This automated rapid processing minimizes the time the unstable compound is exposed to conditions that cause degradation, preserving its effectiveness while ensuring adequate dosage for pathogen inactivation.
Data Source
AI summary
Provided are methods and systems for the pathogen inactivation of blood products and compositions, including methods of using devices (e.g., comprising component(s) configured to control flow of fluid(s)) to determine the amount of pathogen inactivation compound (PIC) necessary for pathogen inactivation of a blood composition (e.g., based at least in part on one or more input parameters) and allow transfer of the blood composition and the PIC into a container, e.g., of a processing set.