Blood Plasma Separation Membrane with Capillary Collection

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Solution Overview

Problem

Current methods for blood plasma and blood cell separation are inefficient, requiring additional steps, absorbent materials, and higher consumable costs, with lower utilization rates and longer operation times due to the need for absorbent materials and complex handling processes.

Innovation Solution

A blood plasma and blood cell separation device comprising a first body with an injection port and a blood plasma separation membrane, and a second body with a collecting stage that uses capillary force to separate blood plasma, allowing relative movement to direct the plasma into a sampling recess, eliminating the need for absorbent materials and reducing handling steps.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a blood plasma separation membrane with pores is used to filter blood plasma, then blood plasma and blood cell separation can be achieved, but additional absorbent material is required to absorb the filtered blood plasma, increasing operation time and consumable cost

Engineering Contradiction:
Improveblood plasma separation capabilityVSAvoidoperation time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The invention extracts and removes the absorbent material component from the traditional two-step separation process. The blood plasma separation membrane is designed to directly collect and retain blood plasma on its separation surface, eliminating the need for additional absorbent material and subsequent squeezing operations, thus reducing operation time while maintaining separation reliability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention merges the filtration function and collection function into a single integrated blood plasma separation membrane structure. The membrane not only filters blood plasma from whole blood but also directly collects and retains the separated plasma on its surface, combining multiple functions into one component to eliminate additional handling steps

Inventive Principle:
Principle #5Merging (Combining)

2Quantity of substance

If absorbent material is used to absorb blood plasma from the separation membrane, then blood plasma can be collected, but the blood plasma cannot be completely extruded, resulting in lower utilization rate

Engineering Contradiction:
Improveblood plasma collectionVSAvoidblood plasma utilization rate
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The blood plasma separation membrane performs self-collection of blood plasma through its own structure. The membrane's surface properties and pore structure enable it to automatically retain separated blood plasma on its separation surface without requiring external absorbent materials, ensuring complete plasma recovery and maximizing utilization rate

Inventive Principle:
Principle #25Self-service

3Quantity of substance

If absorbent material is required for blood plasma absorption, then blood plasma can be collected from the separation membrane, but the cost of consumables increases

Engineering Contradiction:
Improveblood plasma collectionVSAvoidconsumable cost
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The invention extracts and eliminates the absorbent material component from the system. The blood plasma separation membrane is designed to directly collect and retain blood plasma on its separation surface through its inherent structural properties, removing the need for additional absorbent materials and thereby reducing consumable costs while maintaining effective plasma collection

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device enables rapid and efficient separation of blood plasma with reduced consumable costs and operation time, achieving higher utilization rates by directly collecting blood plasma without absorbents, allowing for quick and effective sample acquisition with minimal blood volume.

Implementation Method 1

a blood plasma in the blood plasma separation membrane is separated by a capillary force between the collecting stage of the second body and the blood plasma separation membrane

Methodology Applied
Scientific EffectCapillary force: Capillary Action

Data Source

PatentEP3395431B1Blood plasma and blood cell separation device and method
Publication Date: 2020.10.07 SKYLA CORP HSINCHU SCI PARK BRANCH
  • EP3395431B1 patent drawingFigure 1A
  • EP3395431B1 patent drawingFigure 1B
  • EP3395431B1 patent drawingFigure 1C~1D

AI summary

A blood plasma and blood cell separation device (100) includes a first body (110), a blood plasma separation membrane (120) and a second body (130). The first body has an injection port (112). The blood plasma separation membrane is disposed on the first body. The second body is movably assembled to the first body and has a collecting stage (132). The collecting stage has a collecting surface (133) and a sampling recess (134) on the collecting stage. When a blood enters the blood plasma separation membrane from the injection port of the first body, a blood plasma in the blood plasma separation membrane is separated by a capillary force between the collecting stage of the second body and the blood plasma separation membrane, and the blood plasma enters in the sampling recess by a relative movement between the first body and the second body.