Centrifugal Separator for Blood Preservation Liquid Mixing
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Solution Overview
Problem
Current methods for adding preservation liquids to blood components, such as red cell components with high hematocrit (Ht) values, are cumbersome and costly due to the need for multiple devices and risk of filter clogging, as these components are viscous and difficult to mix effectively.
Innovation Solution
A chemical liquid addition system that integrates a centrifugal separator to mix and add preservation liquids to blood components using centrifugal force, reducing the need for multiple devices and enhancing efficiency by using a flow path and mixing device to combine blood components with preservation liquids within the centrifugal separator.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If red cell components with high Ht values are passed through a filter, then white blood cells can be removed, but the red blood cells may be destroyed and the filter may clog due to high viscosity
Solution Approach 1:
The preservation liquid is added to the red cell components before filtration to dilute the high Ht value and reduce viscosity in advance. This preliminary dilution prevents filter clogging and red blood cell destruction during the filtration process, while maintaining the necessary white blood cell removal function.
Solution Approach 2:
The preservation liquid acts as an intermediary substance that facilitates the filtration process by reducing the viscosity of red cell components. By introducing this intermediate fluid, the system enables smooth passage through the filter without direct contact between high-viscosity red cells and the filter medium, preventing clogging.
2Reliability
If multiple devices (centrifugal separator and blood component separation device) are used for preservation liquid addition, then blood components can be separated and preserved, but the process becomes time-consuming and costly
Solution Approach 1:
The invention combines the centrifugal separation function and preservation liquid addition function into a single integrated device. The centrifugal separator now performs both the separation of blood components and the simultaneous addition of preservation liquid, eliminating the need for separate transfer operations and reducing overall processing time while maintaining separation quality.
Solution Approach 2:
The centrifugal separator is designed with multi-functionality, serving both as a separation device and as a preservation liquid addition device. This universal design allows the same device to perform multiple functions that previously required separate specialized equipment, reducing both time and cost.
3Ease of operation
If red cell components are centrifugally separated and then transferred to a mixing bag for manual mixing, then preservation liquid can be added, but the process becomes cumbersome and requires multiple device transfers
Solution Approach 1:
The mixing function is merged into the centrifugal separator by incorporating a mixing device that operates within the same device used for separation and preservation liquid addition. This eliminates the need for separate mixing bags and manual mixing operations, making the entire process more streamlined and easier to operate.
Solution Approach 2:
The system performs mixing automatically through the mixing device integrated in the centrifugal separator, eliminating the need for manual shaking or external mixing equipment. The device serves itself by completing all operations (separation, preservation liquid addition, and mixing) within a single integrated system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables easy and timely addition of preservation liquids to blood components, reducing costs and processing time while effectively removing undesired substances using a single centrifugal separator, thereby improving the efficiency and cost-effectiveness of blood component preparation.
Implementation Method 1
blood in the blood pack is centrifugally separated into multiple blood component layers by the centrifugal separator
Implementation Method 2
by centrifugal force of the centrifugal separator
Implementation Method 3
a mixing device that mixes the body fluid component sent from the body fluid bag with the chemical liquid sent from the chemical liquid bag in the flow path while the body fluid component and the chemical liquid flow therethrough
Data Source
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AI summary
The preservation liquid addition system of the present invention enables a chemical liquid to be added to a blood cell component both easily and in a short period of time. The preservation liquid addition system is able to be placed on a centrifugal separator. The preservation liquid addition system has a blood bag, a preservation liquid bag, a mixed liquid bag, a first flow path and a static mixer. A blood component in the blood bag and a preservation liquid in the preservation liquid bag are sent to the static mixer through the first flow path, and a mixed liquid mixed by the static mixer is sent to the mixed liquid bag by centrifugal force of the centrifugal separator.