Blood Pressure Stimulation Pattern Tuning for Patient-Specific Therapy
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Solution Overview
Problem
Existing cardiac stimulation therapies for blood pressure reduction lack customization to individual patient physiology, leading to inefficiencies and potential instability in blood pressure regulation.
Innovation Solution
A method and system for customizing blood pressure reduction stimulation therapy by establishing baseline parameters, applying predefined patterns, calculating new patterns if necessary, and determining the most suitable stimulation pattern based on parameters like average systolic measurement, slope, and error, using a controller to adjust atrioventricular delays iteratively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a single standardized stimulation pattern is used for all patients, then the device complexity is reduced, but the therapy effectiveness and adaptability to individual patient physiology deteriorates
Solution Approach 1:
The system dynamically adjusts stimulation parameters including atrioventricular delay, pulse width, and stimulation timing based on real-time blood pressure measurements and patient-specific physiology. The controller continuously optimizes the stimulation pattern to achieve target blood pressure reduction while adapting to individual patient responses, thereby resolving the contradiction between adaptability and complexity.
Solution Approach 2:
The invention systematically varies multiple stimulation parameters (atrioventricular delay, pulse width, stimulation frequency) to create customized therapy regimens for each patient. By changing these parameters based on measured blood pressure responses and patient characteristics, the system achieves individualized therapy optimization without requiring a completely complex device architecture.
2Reliability
If multiple customized stimulation patterns are tested and optimized for each patient, then the therapy effectiveness is improved, but the setup time and loss of time increases
Solution Approach 1:
The system performs preliminary blood pressure measurements and physiological assessments during an initial calibration period to establish baseline parameters and predict optimal stimulation characteristics. This preliminary characterization allows the system to pre-configure stimulation parameters before full therapy initiation, reducing the time required for ongoing adjustments while maintaining high therapy effectiveness.
Solution Approach 2:
The system implements continuous feedback loops where blood pressure measurements are constantly monitored and used to automatically adjust stimulation parameters. This closed-loop control enables rapid convergence on optimal therapy settings without requiring extensive manual setup time, as the system self-optimizes based on real-time physiological responses.
3Measurement precision
If stimulation parameters are continuously adjusted to optimize blood pressure reduction, then the therapy precision is improved, but the device complexity and difficulty of detecting and measuring increases
Solution Approach 1:
The system uses the patient's own blood pressure measurements and physiological responses as the basis for optimizing stimulation parameters. The controller automatically analyzes blood pressure data, identifies patterns, and adjusts stimulation settings without requiring external intervention or complex measurement systems. This self-service approach maintains high measurement precision while avoiding additional complexity in detection and measurement infrastructure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Achieves a stable and optimized blood pressure reduction tailored to individual patient needs, maintaining therapeutic effects over time by iteratively adjusting stimulation patterns to meet designated acceptance criteria.
Implementation Method 1
modulating the baroreflex that responds to the reduction in pressure
Data Source
AI summary
Methods and systems for customizing blood pressure reduction stimulation therapy for a patient are disclosed, which according to an embodiment, may involve establishing baseline blood pressure parameters of a patient; applying predefined stimulation patterns and determining if any predefined stimulation patterns meet designated acceptance criteria; if no predefined stimulation patterns meet the designated acceptance criteria, calculating and applying new stimulation patterns and determining if any new stimulation patterns meet the designated acceptance criteria; determining, from among the applied predefined stimulation patterns and the applied new stimulation patterns, a stimulation pattern most suitable for the patient; and applying the most suitable stimulation pattern to the patient.