Blood Processing Device Plasma Collection Segmentation
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Solution Overview
Problem
Current blood processing systems are unable to collect plasma from a single whole blood unit into multiple plasma product bags, resulting in transfusion plasma products exceeding 180 mL, which does not offer additional value and limits the value of plasma products.
Innovation Solution
A blood processing device and system that includes a pump system, valve system, and controller to separate blood into plasma and red blood cells, allowing for the collection of a first volume of plasma for transfusion and a second volume for fractionation, enabling the collection of plasma into separate containers to maximize product value.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If plasma is collected from a single whole blood unit into a single container, then the collection process is simple, but the plasma volume exceeds 180 mL which does not offer additional value for transfusion plasma products
Solution Approach 1:
The plasma collection process is segmented into two distinct collection pathways: a first collection container for transfusion plasma (minimum 180 mL) and a second collection container for fractionation plasma (remaining volume). This segmentation allows the system to capture value from both transfusion and fractionation markets, transforming excess plasma volume from a waste problem into a dual-product solution.
2Quantity of substance
If the blood processing system is configured to collect plasma into multiple containers, then the value of plasma products is maximized, but the device complexity increases
Solution Approach 1:
The system employs dynamic valve control to switch between different collection pathways during the plasma separation process. The valve system can be actuated to direct plasma flow to either the first collection container (for transfusion) or the second collection container (for fractionation), allowing flexible adaptation to different product requirements without requiring multiple fixed processing lines.
Solution Approach 2:
The blood processing system is designed with multi-functionality to handle both transfusion plasma and fractionation plasma collection through a single integrated platform. The same plasma separation chamber and pumping system serve dual purposes, with the valve system enabling route selection to different collection containers based on the desired product type.
3Quantity of substance
If plasma volume for transfusion exceeds 180 mL, then more plasma is available for transfusion use, but the additional volume does not offer additional value
Solution Approach 1:
The system extracts the valuable fractionation plasma component from the excess plasma volume that would otherwise be wasted. By separating and collecting the remaining plasma (beyond the 180 mL transfusion requirement) into a dedicated second container, the system recovers economic value from what would be considered excess or waste material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the collection of plasma products in specific volumes, allowing for the production of transfusion plasma with a minimum required volume and fractionation plasma valued by unit volume, thereby increasing the overall value of plasma products derived from a single unit of whole blood.
Implementation Method 1
The centrifuge rotates the separation chamber of the disposable flow circuit during processing, causing the heavier (greater specific gravity) components of the whole blood in the separation chamber, such as red blood cells, to move radially outwardly away from the center of rotation toward the outer or 'high-G' wall of the separation chamber. The lighter (lower specific gravity) components, such as plasma, migrate toward the inner or 'low-G' wall of the separation chamber.
Data Source
AI summary
A blood processing device includes a pump system, a valve system, a separator and a controller configured to execute a plasma collection stage of a blood processing procedure by actuating the pump system and the valve system to convey blood from a blood source into the separator, actuating the separator to separate the blood into at least plasma and red blood cells, in a transfusion plasma collection step actuating the pump system and the valve system to convey a first volume of separated plasma out of the separator along a first flow path for transfusion plasma collection, and in a fractionation plasma collection step of the plasma collection stage, actuating the pump system and valve system to convey a second volume of the separated plasma out of the separator along a second flow path for fractionation plasma collection.