Blood Pump ML Estimation of Cardiac Output Without Catheters
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Solution Overview
Problem
Clinicians face challenges in determining the optimal support duration and amount for cardiac assist devices due to the difficulty in quantitatively assessing cardiac function, often relying on indirect estimates and invasive diagnostic methods that can be risky and imprecise.
Innovation Solution
A machine learning model is developed using neural networks to relate blood pump parameters to cardiac parameters, enabling estimation of cardiac output and left ventricular volume without additional catheters, by analyzing data from a patient population and applying it to individual patients based on demographics and conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluid-filled catheters are used to measure cardiac parameters, then measurement precision is improved, but object-affected harmful factors increase due to patient risk and potential interference with pumping device functionality
Solution Approach 1:
The patent creates a virtual copy of the catheter measurement system through machine learning models. The model is trained on data from patients with catheters to learn the relationship between pump parameters and cardiac parameters. Once trained, the model can estimate cardiac parameters from pump parameters alone, creating a software-based copy that eliminates the need for physical catheters in routine monitoring while maintaining measurement precision.
Solution Approach 2:
The patent replaces the mechanical catheter-based measurement system with a computational model. Instead of physically inserting catheters to measure cardiac parameters, the system uses machine learning algorithms that process pump parameter data to estimate cardiac function. This substitution eliminates the mechanical intrusion while preserving the ability to obtain accurate cardiac parameter measurements.
2Adaptability or versatility
If machine learning models are applied to all patients, then adaptability is improved, but manufacturing precision decreases due to variability in model accuracy across different patient populations
Solution Approach 1:
The patent segments the patient population into different groups based on characteristics such as disease state, demographics, and clinical parameters. Multiple specialized models are trained for different patient segments, allowing the system to adapt to specific population characteristics while maintaining high accuracy for each group. The segmentation approach enables tailored modeling that preserves precision within each segment while achieving broad adaptability across all patient types.
Solution Approach 2:
The patent implements a dynamic model selection process where the system determines which patient population the current patient belongs to and selects the appropriate pre-trained model. This dynamic adaptation allows the system to maintain high accuracy by matching the right model to the right patient population, rather than using a single static model for all patients.
Data Source
AI summary
Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.


