Blood Purification Device with Concentration Feedback Control
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Solution Overview
Problem
In blood purification apparatuses performing pre-substitution, there is a challenge of excessive blood concentration due to insufficient dialysate supply, leading to inadequate dilution and filtration inefficiencies, especially when the substitution pump is driven rapidly.
Innovation Solution
A blood purification apparatus with a control device that measures or calculates blood concentration in the dilution channel section and adjusts the flow rate of the substitution fluid based on these measurements to prevent excessive concentration, using a substitution supplying device and a calculation or measurement device to ensure proper dilution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the substitution pump is driven rapidly to perform pre-substitution, then the substitution speed is improved, but the blood concentration becomes excessively high due to insufficient dialysate supply
Solution Approach 1:
The control device monitors the actual blood concentration in the dilution channel section and adjusts the substitution pump speed accordingly. When blood concentration exceeds the target range, the system automatically reduces the substitution pump speed to prevent excessive concentration, creating a closed-loop feedback control mechanism that balances substitution speed with concentration control
Solution Approach 2:
The substitution pump speed is made dynamically adjustable rather than operating at a fixed high speed. The control device continuously modifies the pump speed based on real-time blood concentration measurements, allowing the system to adapt between high-speed substitution and concentration control as needed
2Quantity of substance
If a predetermined amount of dialysate is supplied to the arterial blood circuit, then the dilution effect is improved, but the filtration using the dialyzer is reduced and blood becomes excessively concentrated
Solution Approach 1:
The system uses feedback control to monitor blood concentration in the dilution channel section and adjusts the substitution pump speed to maintain optimal balance between dilution and filtration. This prevents excessive concentration while ensuring sufficient dialysate supply for effective filtration
Solution Approach 2:
The control device dynamically changes the substitution pump speed parameter based on real-time blood concentration measurements. By adjusting this key parameter, the system optimizes the balance between dialysate supply for dilution and maintains adequate filtration throughput
3Productivity
If the substitution pump is driven faster than in post-substitution, then the substitution speed is improved, but the excessive concentration is easily generated
Solution Approach 1:
The control device continuously monitors blood concentration in the dilution channel section and adjusts the substitution pump speed in real-time. This feedback mechanism prevents excessive concentration even when operating at high substitution speeds, making the system safer than conventional high-speed pre-substitution methods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution effectively prevents excessive blood concentration by accurately controlling the substitution fluid flow rate, ensuring efficient dilution and filtration, and maintaining optimal blood concentration during the blood purification process.
Implementation Method 1
a blood purifier (1) which performs blood purification in a blood purification membrane
Implementation Method 2
there is a need to perform the substitution (including a pre-substitution performing substitution by the arterial blood circuit, and a post-substitution performing substitution by the venous blood circuit) of the dialysate to the patient's blood by the ultrafiltration corresponding to a filtration treatment as the HDF treatment
Implementation Method 3
the dialysate in a dialysate introduction line is supplied to the blood circuit (the arterial blood circuit or the venous blood circuit) by driving the substitution pump
Implementation Method 4
the blood diluted by the substitution is filtrated
Implementation Method 5
a blood pump disposed in the arterial blood circuit
Data Source
Figure 1
Figure 2~3
Figure 4
AI summary
[object] Disclosed is a blood purification apparatus capable of preventing excess concentration in blood circulating extracorporeally during online HDF or online HF performing a pre-substitution. [Solution] The blood purification apparatus is equipped with a dialyzer 1, an arterial blood circuit 2 in which a blood pump 4 has been disposed, a venous blood circuit 3, a dialysate introduction line L1 that introduces a dialysate to the dialyzer 1, a dialysate discharge line L2 that discharges the dialysate from the dialyzer 1, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2, wherein a control device 11 is provided capable of estimating or measuring the concentration of blood in a dilution channel section A; on the arterial blood circuit 2 that includes the fluid channel spanning from the connection site of the substitution line L3 to the dialyzer 1, and that controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.