Blood Sample Collection Device with Integrated Plasma Separation
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Solution Overview
Problem
Conventional blood sample collection techniques require high volumes of blood, making alternate, less invasive methods less favorable due to insufficient blood volume for conventional testing, and adding complexity in separating samples for different processing steps.
Innovation Solution
A device with multiple sample collection pathways and containers that utilize a separation material to separate formed components from the blood sample, allowing for simultaneous collection and separation of blood and plasma into separate outlets from a single sample, using capillary action and pressure differentials to facilitate efficient sample transfer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional venipuncture is used to obtain sufficient blood volume for testing, then the required blood volume is achieved, but patient apprehension and invasiveness increase
Solution Approach 1:
The device divides the blood sample into multiple separate collection tubes simultaneously through a single capillary puncture. The sample is segmented into different portions that can be directed to different tubes based on their composition (whole blood, plasma, serum), eliminating the need for large-volume draws while providing sufficient material for multiple tests.
Solution Approach 2:
The device uses an intermediary mechanism (capillary action and separation media) to automatically divide and direct the small blood sample into appropriate collection tubes. This intermediary system enables efficient sample utilization from minimal blood volume, reducing the need for invasive venipuncture.
2Object-affected harmful factors
If alternate site puncture is used to reduce invasiveness, then patient comfort improves, but sufficient blood volume for conventional testing cannot be obtained
Solution Approach 1:
The device segments the limited blood sample from alternate site puncture into multiple usable portions, maximizing the utility of each microliter obtained. By dividing the sample into different collection tubes with specific functions, the device enables conventional testing volumes to be achieved from minimal blood extraction.
Solution Approach 2:
The device changes the parameter of sample volume efficiency by using capillary action and automated separation to multiply the utility of small blood volumes. This parameter change allows alternate site puncture to provide sufficient material for conventional testing methodologies.
3Ease of operation
If traditional collection technique is used, then sample collection is achieved, but complexity in separating samples for different processing steps increases
Solution Approach 1:
The device merges multiple functions (sample collection, separation, and distribution) into a single integrated system. By combining these operations that would traditionally require separate steps and equipment, the device simplifies the overall process while maintaining ease of sample collection.
Solution Approach 2:
The device provides multi-functionality by simultaneously collecting, separating, and distributing samples for different processing steps through a single operation. This universal device replaces multiple separate procedures, reducing complexity while maintaining operational simplicity.
4Quantity of substance
If high volume blood extraction is required for conventional testing, then sufficient sample material is obtained, but the need for multiple collection and processing steps increases
Solution Approach 1:
The device segments the blood sample into functionally distinct portions that can be directly used for different testing purposes. This segmentation eliminates redundant processing steps by providing pre-separated samples in appropriate containers, thereby maintaining sufficient material volume while improving processing efficiency.
Solution Approach 2:
The device performs preliminary separation and distribution actions during the collection phase itself. By preparing the sample in its final separated form before testing begins, the device eliminates subsequent processing steps, improving productivity while obtaining sufficient sample material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient collection and separation of blood and plasma from a single sample, reducing the need for high blood volumes and simplifying the processing of samples into different containers, improving patient compliance and reducing complexity in sample handling.
Implementation Method 1
a separation material positioned along the first pathway between the sample inlet and the first outlet, the separation material configured to remove formed components from the sample prior to outputting the liquid portion at the first outlet
Implementation Method 2
using capillary action and pressure differentials to facilitate efficient sample transfer
Implementation Method 3
using capillary action and pressure differentials to facilitate efficient sample transfer
Data Source
AI summary
Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.