Blood Sample Sensor Chip for Temperature-Accurate Glucose Testing

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Solution Overview

Problem

Existing biosensor systems inaccurately measure analyte concentration due to temperature discrepancies between the measuring instrument and the blood sample, especially during sudden environmental temperature changes, leading to measurement errors.

Innovation Solution

A biosensor system with a sensor chip that measures temperature and concentration by applying specific voltages to electrodes, where the first voltage for temperature measurement is higher than the second voltage for concentration measurement, minimizing the impact of glucose and hematocrit variations, and using a capillary to introduce the biological sample.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a temperature sensor is disposed in the measuring instrument to measure reaction temperature, then the temperature measurement function is provided, but the measurement accuracy deteriorates because the instrument temperature does not accurately reflect the blood sample temperature

Engineering Contradiction:

Improvetemperature measurement accuracyVSAvoidtemperature representation accuracy

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

A thermal conductive member is introduced as an intermediary between the blood sample holder and the temperature sensor. This mediator transfers heat from the blood sample to the sensor, allowing accurate temperature measurement without direct contact between the sensor and sample, thus resolving the contradiction between measurement function and accuracy

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the direct thermal contact mechanism with a thermal conduction field through the thermal conductive member. This substitution allows temperature information to be transmitted through thermal fields rather than direct mechanical contact, improving measurement accuracy while maintaining system functionality

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If a resin plate is disposed between the thermal conductive member and the blood sample holder to prevent contact, then the blood sample is protected from direct contact, but the thermal conduction efficiency deteriorates

Engineering Contradiction:

Improveblood sample protectionVSAvoidthermal energy loss

Core Design Contradiction:

ReliabilityVSLoss of energy

Solution Approach 1:

The patent changes the thermal parameter of the intervening material by using a resin plate with specific thermal conductivity properties. This parameter optimization allows the plate to provide adequate protection while maintaining sufficient thermal conduction efficiency, resolving the contradiction between protection and energy loss

Inventive Principle:

Principle #35Parameter changes

3Adaptability or versatility

If the measuring instrument is moved between environments with large temperature differences, then the adaptability to different environments is provided, but the measurement accuracy deteriorates due to temperature equilibrium time delay

Engineering Contradiction:

Improveenvironmental adaptabilityVSAvoidanalyte concentration measurement accuracy

Core Design Contradiction:

Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent replaces the indirect temperature measurement method (measuring instrument temperature) with a direct blood sample temperature measurement method using the thermal conductive member. This substitution eliminates the temperature equilibrium delay problem, allowing accurate measurements immediately after environmental changes while maintaining environmental adaptability

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Accurately measures blood sample temperature and analyte concentration, reducing measurement errors by isolating the effects of temperature changes and hematocrit variations, thereby enhancing precision.

Implementation Method 1

a temperature measurement of measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured

Methodology Applied

Scientific EffectJoule heating: Joule Heating

Implementation Method 2

a capillary allowing the biological sample to be introduced therein

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Data Source

PatentEP3450969B1Sensor chip for measuring temperature of biological sample and concentration of analyte in the biological sample

Publication Date: 2025.07.16 PHC HLDG CORP

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AI summary

A sensor chip (200) is configured to measure the temperature of a blood sample and includes a capillary section (40) and an electrode unit (11, 12). The capillary section (40) allows the blood sample to be introduced therein. The electrode unit (11, 12) is configured to measure the temperature of the blood sample and includes a working electrode and a counter electrode. The working electrode and the counter electrode respectively include a reaction reagent layer (20) containing an electrolyte. Further, the electrode unit (11, 12) is configured to receive a predetermined voltage to be applied in measuring the temperature of the blood sample for allowing a result of the measurement to be less affected by increase and reduction in a glucose concentration and the like.