Blood Sample Sedimentation Analysis Using Optical Sensors

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Solution Overview

Problem

Current methods for analyzing blood samples are either complex and costly, providing precise but time-consuming and expensive evaluations, or non-specific, offering limited information and requiring further tests for pathology identification.

Innovation Solution

A method involving a simple, low-cost erythrocyte sedimentation rate test using a graduated glass container with optical sensors to measure sedimentation rates, comparing results to reference values to indicate the presence and type of pathology without the need for specialized equipment or personnel, utilizing sedimentation trend analysis to differentiate between healthy and pathological samples.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If specific tests are conducted in a laboratory using specialized equipment, then measurement precision is improved, but device complexity and cost increase

Engineering Contradiction:
Improvepathology detection precisionVSAvoidequipment complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent creates a simplified copy of the laboratory sedimentation test that can be performed at home. The portable device replicates the essential function of measuring erythrocyte sedimentation rate using a small capillary tube and basic optical sensor, eliminating the need for complex laboratory equipment while maintaining diagnostic capability

Inventive Principle:
Principle #26Copying

Solution Approach 2:

The invention uses disposable or simple reusable components such as capillary tubes, basic optical sensors, and microprocessor units that can be manufactured at low cost. These components replace expensive laboratory equipment while providing sufficient functionality for pathology screening

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Measurement precision

If specific tests are conducted in a laboratory, then measurement precision is improved, but loss of time increases

Engineering Contradiction:
Improvepathology detection precisionVSAvoidanalysis time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent divides the blood sample analysis into discrete, rapid measurement steps using a capillary tube format. The sedimentation process is segmented into measurable intervals within the tube, allowing for quick automated reading at specific time points rather than requiring continuous laboratory monitoring

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention replaces complex laboratory mechanical and optical systems with a simplified portable device using basic optics and microprocessor control. The automated optical detection system quickly measures sedimentation distance without requiring manual observation or complex laboratory infrastructure

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Loss of time

If non-specific tests are used, then loss of time and cost are reduced, but loss of information increases

Engineering Contradiction:
Improvetesting timeVSAvoidpathology identification information
Core Design Contradiction:
Loss of timeVSLoss of information

Solution Approach 1:

The patent measures the dynamic sedimentation process at multiple time points rather than a single endpoint measurement. By tracking the sedimentation rate changes over time, the system captures more information about blood characteristics, enabling better pathology differentiation while maintaining quick testing

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The device provides immediate automated feedback through the microprocessor and display, comparing measured values against reference ranges to indicate potential pathologies. This instant feedback mechanism compensates for the simplified test design by providing intelligent interpretation that recovers diagnostic information

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables specific and cost-effective analysis of blood samples for pathology identification, reducing the need for extensive laboratory procedures and enabling monitoring of health conditions over time with minimal equipment and expertise.

Implementation Method 1

measuring a rate V at which corpuscular components (1a) contained in the blood sample (1) settle on the bottom of the container (2)

Methodology Applied
Scientific EffectSedimentation: Sedimentation

Implementation Method 2

The blood sample is then allowed to sediment, with the test tube set in a predetermined position, in order to be able to measure the rate V at which the corpuscular components (1a) contained in the blood sample (1) settle on the bottom of the container (2)

Methodology Applied
Scientific EffectGravitation: Gravitation

Data Source

PatentEP3105585B1A method for analyzing blood samples for detection of pathologies
Publication Date: 2022.04.06 GRADEMI BIOTECH SRL
  • EP3105585B1 patent drawingFigure 1
  • EP3105585B1 patent drawingFigure 2
  • EP3105585B1 patent drawingFigure 3

AI summary

A method for analyzing blood samples, comprising the steps of: preparing a blood sample (1) within a respective container (2) provided with an anticoagulant substance; measuring the rate (V) at which the corpuscular components (1a) contained in the blood sample (1) sediment on the bottom of said container (2), said rate (V) being measured over a predetermined time period (T); detecting, within said time period (T), at least one sedimentation trend (A1, A2, A3) representative of steps of aggregation of the corpuscular components (1 a); and comparing the detected sedimentation trend (A1, A2, A3) with at least one reference parameter (P1, P2, P3) representative of at least one given pathology.