Blood Sensor Electrode Mediator Placement for Hct Correction
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Solution Overview
Problem
Conventional methods for measuring blood components, such as glucose, face challenges in accurately correcting the measured values due to the inaccuracy and unreliability of hematocrit (Hct) values, which affect the precision of blood component measurements.
Innovation Solution
A method and device that measure blood components by inducing a redox reaction between blood components and oxidoreductase in the presence of a mediator, with a separate electrode system for Hct measurement, where a mediator is only provided on the counter electrode, allowing for high-accuracy detection of Hct values to correct the blood component measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional methods with mediators on both electrodes are used for Hct measurement, then the measurement can be performed, but the accuracy and reliability of the Hct value is insufficient
Solution Approach 1:
The patent applies local quality by placing the mediator only on the counter electrode rather than on both electrodes. This creates a localized functional difference: the working electrode surface remains free of mediator to prevent direct electron transfer with blood components, while the counter electrode retains the mediator for completing the electrical circuit. This localized arrangement eliminates the interference that caused inaccurate and unreliable Hct measurements in conventional methods.
2Ease of operation
If mediators are provided on both working electrode and counter electrode, then the electrode system can function, but the blood component measurement is affected by inaccurate Hct values
Solution Approach 1:
The patent extracts the mediator from the working electrode surface, removing only the necessary amount while keeping it on the counter electrode. This extraction eliminates the harmful effect of mediator-blood component interactions at the working electrode that led to inaccurate Hct values, while preserving the essential functionality of the electrode system through the mediator's presence on the counter electrode.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables highly accurate and reliable correction of blood component measurements by using the measured Hct values, improving the precision and reliability of the results.
Implementation Method 1
causing a redox reaction between the component in the blood and an oxidoreductase in the presence of a mediator
Implementation Method 2
a current flows via the mediator. The current is detected
Implementation Method 3
detecting an oxidation current or a reduction current caused through the redox reaction by an electrode system
Implementation Method 4
providing a mediator on the counter electrode but not on the working electrode
Implementation Method 5
causing an oxidation current or a reduction current to flow between the electrodes
Data Source
AI summary
The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (11,12). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.