Blood Component Separation with Dilution for Virus Inactivation
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Solution Overview
Problem
Existing blood component separation devices are inefficient in performing virus inactivation processes, particularly for blood products containing red blood cells, as UV light is absorbed or reflected, leading to incomplete virus inactivation and prolonged processing times.
Innovation Solution
A blood component separation device and method that involves diluting the separated blood components in a photoactive virus inactivation agent, allowing for easier UV light penetration and enhanced virus inactivation efficiency, combined with a concentration adjustment section to refine the component concentration post-inactivation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If UV light is emitted to inactivate viruses in concentrated red blood cells, then virus inactivation is achieved, but the UV light is absorbed or reflected by red blood cells, making the process inefficient and time-consuming
Solution Approach 1:
The patent changes the concentration parameter of red blood cells by diluting them before virus inactivation. This parameter change reduces the absorption and reflection of UV light, allowing the light to penetrate deeper into the blood product and inactivate viruses more effectively and quickly throughout the entire volume, not just at the surface.
2Productivity
If red blood cells are diluted to improve UV light penetration, then virus inactivation efficiency is enhanced, but the concentration of the blood product is reduced
Solution Approach 1:
The patent performs preliminary dilution of red blood cells before virus inactivation to enable efficient UV light penetration. After the inactivation process is complete, the blood product is then concentrated back to the desired level. This preliminary action sequence allows both efficient virus inactivation and maintenance of appropriate final concentration.
Solution Approach 2:
The patent implements a periodic process where the blood product undergoes dilution for inactivation, then concentration to restore desired levels. This periodic alternation between dilution and concentration states enables both efficient virus inactivation and maintenance of appropriate blood product concentration for clinical use.
3Reliability
If centrifugation is performed to separate blood components, then blood components are successfully separated, but additional time is required for subsequent virus inactivation processing
Solution Approach 1:
The patent changes the concentration parameter of separated blood components by diluting them before virus inactivation. This allows the inactivation process to be performed more quickly and efficiently, reducing the overall processing time while maintaining effective virus inactivation throughout the blood product volume.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables rapid and effective virus inactivation of blood components, reducing processing time and allowing for the efficient collection of blood components with desired concentrations, while potentially downsizing the device.
Implementation Method 1
a blood component separation section for separating a blood component from blood by centrifuging the blood
Implementation Method 2
a diluting section for diluting, in a diluent containing a photoactive virus inactivation agent, the blood component separated by the blood component separation section
Implementation Method 3
a blood-component virus inactivation section for performing a virus inactivation process by emitting light to the diluted blood component
Data Source
AI summary
Provided is a blood component separation device and related method, each capable of separating a blood component from blood and rapidly performing a virus inactivation process on the separated blood component. The blood component separation device includes a blood component separation section, provided in a centrifuge, configured to separate a blood component from blood by centrifugation, a diluting section configured to dilute, in a diluent containing riboflavin, concentrated red blood cells separated by the blood component separation section, and a UV light emitting unit configured to perform a virus inactivation process by exposing the concentrated red blood cells thus diluted to the UV light.