Blood Component Separation Device with Dynamic Platelet Collection Control
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Solution Overview
Problem
Conventional blood component separation devices are inefficient in collecting high-concentration platelet liquid, as the amount collected in the last cycle is similar to other cycles, leading to reduced overall platelet collection efficiency.
Innovation Solution
A blood component separation device that includes a centrifugal separator and a temporary storage container, where the second blood component with low-concentration from the previous cycle is mixed with whole blood in subsequent cycles to increase platelet concentration, allowing for greater collection in the last cycle, and varying the amount of high-concentration platelet liquid collected in each cycle to ensure efficient collection across all cycles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the same amount of high-concentration platelet liquid is collected in each cycle, then the collection process is simple to control, but the overall platelet collection efficiency is reduced
Solution Approach 1:
The patent implements dynamic adjustment of the collection amount of high-concentration platelet liquid across different cycles. The collection amount varies from cycle to cycle based on a predetermined pattern, allowing the system to adapt to changing platelet concentrations in the centrifugal separator. This dynamic approach maximizes total platelet collection efficiency while maintaining manageable control complexity through automated programming of the collection amounts for each cycle.
Solution Approach 2:
The patent changes the parameter of collection amount from a fixed value to a variable value that differs across cycles. By setting different collection amounts for different cycles (e.g., collecting less in early cycles when concentration is lower and more in later cycles when concentration is higher), the system optimizes overall platelet recovery. This parameter change is implemented through the control unit that manages the collection process based on predetermined cycle-specific amounts.
2Quantity of substance
If low-concentration platelet liquid is stored in the platelet intermediate bag, then the bag can be used for future collections, but the concentration of platelet liquid in the bag is reduced
Solution Approach 1:
The patent extracts and separates low-concentration platelet liquid from the platelet intermediate bag before it can dilute the stored high-concentration platelet liquid. By removing the low-concentration portion that would otherwise be mixed in, the system preserves the high concentration of the stored platelet liquid while still allowing the bag to accumulate sufficient volume for future collections. This extraction prevents concentration degradation while maintaining storage capability.
Solution Approach 2:
The patent segments the platelet liquid collection process into different concentration zones and handles them separately. Low-concentration platelet liquid is identified and separated from high-concentration platelet liquid through the segmentation of collection streams. This allows the system to store different concentration levels in different containers or at different times, preventing dilution of the high-concentration stock while maintaining overall collection efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration enables the efficient collection of a greater amount of high-concentration platelet liquid, reducing the time required for blood drawing and minimizing donor stress, while also reducing the need for additional equipment and costs.
Implementation Method 1
a centrifugal separator for separating a predetermined blood component from blood
Data Source
AI summary
A blood component separation device includes a centrifuge bowl for separating a blood component from blood, a plasma bag for storing a plasma component, a platelet intermediate bag for storing high-concentration platelet liquid having high-concentration of platelets, and a temporary storage bag (also used as a buffy coat bag) for storing low-concentration platelet liquid having low-concentration of platelets. The blood component separation device performs control, from the second cycle onward, to mix the low-concentration platelet liquid stored in the temporary storage bag in the immediately preceding cycle with whole blood to supply the mixed liquid to the centrifuge bowl. An amount of high-concentration platelet liquid to be collected in the platelet intermediate bag in the first cycle is set to be smallest among all cycles, and an amount of high-concentration platelet liquid to be collected in a last cycle is set to be greatest among all the cycles.